OBJECTIVE To evaluate the efficacy and safety of ABT-494, a selective JAK-1 inhibitor, in patients with moderate-to-severe rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX). METHODS Three hundred RA patients receiving stable doses of MTX were randomly assigned equally to receive immediate-release ABT-494 at 3, 6, 12, or 18 mg twice daily, 24 mg once daily, or placebo ...

Oral squamous cell carcinoma (OSCC) is the most common malignancy of head and neck. Although radiotherapy is used for OSCC treatment, the occurrence of radioresistant cancer cells limits its efficiency. MicroRNAs (miRNAs) are non-coding RNAs with lengths of 18-25 base pairs and known to be involved in carcinogenesis. We previously demonstrated that by targeting B lymphoma Mo-MLV insertion regio...

The Promise of ASSIST: Shaping the Future ............................................................... 484 Ecological Theory and the ASSIST Conceptual Framework ................................................. 484 Interventions for Systems-Level Change ........................................................................... 484 Media Advocacy ................................................

INTRODUCTION. .................................................................. 488 Description of Drosophila simulans. ................................................ 488 Distribution of Drosophila simulans ................................................ 491 Discovery of Drosophila simulans. ................................................. 491 Drosophila melanogaster 0 X D . simulans 61. ....

TaGW2 is an orthologue of rice gene OsGW2, which encodes E3 RING ubiquitin ligase and controls the grain size in rice. In wheat, three copies of TaGW2 have been identified and mapped on wheat homoeologous group 6 viz. TaGW2-6A, TaGW2-6B and TaGW2-6D. In the present study, using as many as 207 Indian wheat genotypes, we identified four SNPs including two novel SNPs (SNP-988 and SNP-494) in the p...

Progress in understanding steps in viral leukemogenesis has often come from the study of mouse strains resistant to the development of leukemia. This approach has led to the identification of mouse genes controlling replication of input leukemia viruses (Fv-1 [1], Fv-4 [2]), replication of defective transforming viruses (Fv-2 [3, 4]), susceptibility to virus-induced immunosuppression (Fv-3 [5])...

Like many marine species with meroplanktonic larvae, the Caribbean spiny lobster (Panulirus argus) has a postlarval stage that moves from the oceanic plankton to inshore nurseries only under specific environmental conditions (i.e., at night, in the surface water layer, on the flood tide, and during new moon), presumably to avoid predation or to enhance onshore transport. Using field and mesocos...

OFFICE HOURS: 1-2 MWF. TEXT: None. I will try to point out the sections of some relevant books, which will address the corresponding material we cover. Some of these books are listed below in bibliography. PREREQUISITE: Math 310 (first course in Linear Algebra), and Stat 401 (Introduction to Probability) or equivalent courses. Basic knowledge of graphs is welcome, (some parts of MCS 261), but n...

INHIBITOR ACM1* Mark C. Hall, Dah-Eun Jeong, James T. Henderson, Eunyoung Choi, Steven C. Bremmer, Anton B. Iliuk, and Harry Charbonneau Biochemistry Department, Purdue Cancer Center, and Bindley Bioscience Center Purdue University, West Lafayette, IN 47907 Running head: Regulation of Acm1 by Cdc28 and Cdc14 Correspondence: Mark C. Hall, 175 S. University St., West Lafayette, IN 47907; Phone: (...