24 Endothelial dysfunction caused by defective NO-signaling plays a pivotal role in the 25 pathogenesis of intermittent claudication (IC). In the present study, we evaluated the 26 acute effects of sildenafil, a phosphodiesterase type 5 inhibitor that acts by prolonging 27 NO-mediated cGMP signaling in vascular smooth muscle, on blood pressure (BP), 28 skeletal muscle oxygenation and walking to...

poly (lactide-co-glycolide)/bioactive glass/hydroxyapatite (pbgha) and poly (lactide-co-glycolide)/ bioactive glass (pbg) nanocomposite coatings with bone. materials and methods: sol-gel derived 58s bioactive glass nanoparticles, 50/50 wt% poly (lactic acid)/poly (glycolic acid) and hydroxyapatite nanoparticles were used to prepare the coatings. the nanocomposite coatings were characterized by ...

Although the wet season in the tropical Amazon (108N–208S) at any one place and in any one year is initiated rapidly by synoptic systems, large-scale thermodynamic conditions modulate the frequency and intensity of these synoptic systems and hence control the climatology of the wet season. In this study, the satellite radiances, radiosondes, and assimilation data of the atmosphere are analyzed ...

BACKGROUND & AIMS Development of resistance results from mutations in the viral genome, and the presence of selective drug pressure leads to the emergence of a resistant virus population. The aim of this study was to analyze the impact of genetic variability on the genetic barrier to drug resistance to DAAs. METHODS The genetic barrier was quantified based on the number and type of nucleotide...

A composite life cycle of the Madden–Julian oscillation (MJO) is constructed using an index based on the first two EOFs of the bandpass-filtered (20–80 days) 850-mb zonal wind averaged from 58N to 58S every 2.58 around the equator. Precipitation, 1000-mb convergence, 850-mb wind, and 200-mb wind are composited for the period 1979–95. Water vapor integrated from the surface to 300 mb is composit...