Synthetic procedures have been developed to provide 2,3-disubstituted-3,4-dihydro-1(2H)-isoquinolinones 6, 10, and 15 from (1R,2S)-ephedrine, (1R,2R)-pseudoephedrine, and L-phenylalanine. Birch reduction of 6 and 10 gave enantiomerically related lactam enolates that were alkylated with methyl iodide, allyl bromide, benzyl bromide, p-benzyloxybenzyl bromide, and p-methoxybenzyl bromide to give 7...

Recent results in the chemistry of disubstituted carbenium ions (vinyl cations and phenyl cations) are described separately under three different sections: From kinetic and solvolytic data of several 1—cyclobutenyl nonaflates, the intermediacy of a non-classical vinyl cation, namely the 1-cyclobutenyl cation 2 is established. Cycloaddition reactions of solvolytically generated vinyl cations wit...

The synthesis of 2,5-disubstituted 5,6-dihydro-lH-pyrido[l,2-a]quinazoline-l,6-diones (3) by reacting monosubstituted bis 2,4,6-trichlorophenyl malonates (1) with 3-aryl-3,4dihydro-2-methyl-4-quinazolinones (2) is described. Allylation of the pyridoquinazoline 3 c with allylbromide afforded the corresponding 3-allyloxy derivative 4. Certain generalizations of the cleavage processes of this seri...

We have identified two subseries of 2,6-disubstituted quinolines, consisting of 6-amide and 6-urea derivatives, which are characterized by fungicidal activity against Candida albicans with minimal fungicidal concentration (MFC) values < 15 µM. The 6-amide derivatives displayed the highest fungicidal activity against C. albicans, in particular compounds 1, 5 and 6 characterized by MFC values of ...

Condensation of 4-amino-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one with different aromatic and heterocyclic aldehydes in dry toluene give schiff bases 3(a-g), which on reaction with thioglycolic acid and thiolactic acid in dry toluene give the corresponding 2,3-disubstituted-4-thiazolidinones 4(a-g) and 2,3-disubstituted-5-methyl-4thiazolidinones 5(a-g). The methylene carbon atom at the position ...

Tandem reactions and consecutive catalysis (or relay catalysis) have been receiving considerable attention in organic synthesis due to their abilities of constructing multiple new chemical bonds to build complex chiral molecules in a single operation. Transition-metal-catalyzed asymmetric hydrogenation is one of the most widely used and reliable catalytic methods for preparation of chiral molec...

Literature survey revealed that a good number of anthracene and substituted anthracences are potential lasing organic compounds. As per Mitsuo Maeda 9,10 dimethyl and 9,10 diphenyl anthracenes exhibit lasing properties around, 435-450nm. In continuation of our studies27 it was proposed to synthesize new lasing organic dyes in particular, new anthracene derivatives and study their photophysical ...

The broad-spectrum aminoglycoside phosphotransferase, APH(3')-IIIa, confers resistance to several aminoglycoside antibiotics in opportunistic pathogens of the genera Staphylococcus and Enterococcus. The profile of the drug resistance phenotype suggested that the enzyme would transfer a phosphate group from ATP to the 3'-hydroxyl of aminoglycosides. In addition, resistance to the 3'-deoxyaminogl...