Histone deacetylases (HDACs) and microRNAs (miRs) have pro-survival roles, but the mechanism behind this is unclear. Repression of ceramide synthase 1 (CerS1), altering C(18) -ceramide generation, was linked to drug resistance and metastasis. Here we report that the CerS1 promoter was repressed by HDAC1-dependent inhibition of Sp1 recruitment to two specific GC-boxes spanning the -177 and -139 ...

This search involved synthesis of several new N-Substituted -3-chloro-
 2-azetidinones which were known as a high medicinal effectiveness for 2,
 4-Diamino-6-hydroxy pyrimidin in two steps. The first step included
 preparation Shiff bases (1-6) by condensation 2, 4-Diamino-6-hydroxy
 with many substituted aldehydes(4-hydroxy benzaldehyde, 2-
 bromobenzaldehyde, 4-dimeth...

Correction for 'Carbonyl trapping and antiglycative activities of olive oil mill wastewater' by Marta Navarro et al., Food Funct., 2015, 6, 574-583.

Parasitic gastrointestinal infections are one of the most important health problems in the developing countries, which lead to the onset of intestinal disease particularly diarrhoea. Due to the particular geographic situation in the Mazandaran province, individuals are infected with various intestinal parasites. The aim of this study was to determine the prevalence rate of enteropathogenic para...

The bile salt export pump (BSEP) is located on the canalicular plasma membrane of hepatocytes and plays an important role in the biliary clearance of bile acids (BAs). Therefore, any drug or new chemical entity that inhibits BSEP has the potential to cause cholestasis and possibly liver injury. In reality, however, one must consider the complexity of the BA pool, BA enterohepatic recirculation ...