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تعداد نتایج: 365907 فیلتر نتایج به سال:
Here, we report suboptimal efavirenz exposure in an obese patient treated with the standard 600 mg dose. Tripling the dose allowed attainment of therapeutic efavirenz concentrations. We developed an in vitro-in vivo extrapolation model to quantify dose requirements in obese individuals. Obesity represents a risk factor for antiretroviral therapy underdosing.
1 Universidad Autonoma del Estado de Morelos, CIICAp, Av. Universidad 1001, 62209 Cuernavaca, Morelos, Mexico 2 Universidad Nacional Autonoma de Mexico, Instituto de Ciencias Fisicas, Av. Universidad s/n, 62210 Cuernavaca, Morelos, Mexico 3 Instituto de Investigaciones Electricas, Reforma 113, 62490 Cuernavaca, Morelos, Mexico 4 Corrosión y Protección (CyP), Buffon 46, 11590 Mexico City, DF, Me...
This paper outlines a method for calibrating a superscalar processor performance model. It is adapted from and integrates well with the existing tools and method used in industry for hardware functional validation. The goal of this study is to identify the risks of developing a performance model with inspection-based validation. It is shown that such a model can exhibit major latency and behavi...
BACKGROUND Health risks such as tobacco use, excessive alcohol consumption and unhealthy body weight contribute to the development of chronic health problems. OBJECTIVE To estimate the associations of tobacco use, excessive alcohol consumption and obesity with healthcare expenditure and chronic diseases among South Africans on a comprehensive medical scheme. METHODS We performed a cross-sec...
Background. Health risks such as tobacco use, excessive alcohol consumption and unhealthy body weight contribute to the development of chronic health problems. Objective. To estimate the associations of tobacco use, excessive alcohol consumption and obesity with healthcare expenditure and chronic diseases among South Africans on a comprehensive medical scheme. Methods. We performed a cross-sect...
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