Two novel six- and seven-dimensional NMR experiments are proposed. The new experiments employ non-uniform sampling that enables achieving high resolution in four indirectly detected dimensions and synchronous sampling in the additional dimensions using projection spectroscopy principle. The resulted data sets could be processed as five-dimensional data using existing software. The experiments f...

Seven members of a family affected by hereditary antithrombin III deficiency were identified. The disorder was associated with recurrent spontaneous episodes of phlebitis, deep venous thrombosis, and pulmonary embolism in middle age. Danazol, a 17-alkyl derivative of ethinyl testosterone, which has been used to treat other antiprotease deficiency states, was assessed in the management of two me...

The purpose of this study was to evaluate the effects of four diets on the results of seven-day Ceriodaphnia dubia toxicity tests. Survival and reproduction were used as indices to detect the sensitivity of this species to acute and chronic copper stress. All toxicity tests were conducted using the moderately hard reconstituted water recommended in 1989 by the U.S. Environmental Protection Agen...

Patients with CHF, NYHA class IV, often fail to achieve adequate plasma CoQ10 levels on supplemental ubiquinone at dosages up to 900 mg/day. These patients often have plasma total CoQ10 levels of less than 2.5 microg/ml and have limited clinical improvement. It is postulated that the intestinal edema in these critically ill patients may impair CoQ10 absorption. We identified seven patients with...

A new species of spirochete which we have called Spirochaeta hebdomadis has been described as the specific etiological agent of seven day fever, a disease prevailing in the autumn in Fukuoka and other parts of Japan. This spirochete is distinguishable from Spirochaeta icterohaemorrhagiae to which it presents certain similarities. Young guinea pigs are susceptible to inoculation with the blood o...

It’s a year since England’s health secretary, Jeremy Hunt, gave a speech linking his government’s promise of “truly seven day” NHS services with changes to contracts for the junior doctors and consultants supposed to enable this. He has suggested that a need for more “senior decision makers” (consultants) at evenings and weekends justified changes to trainees’ contracts. Meanwhile, however, the...

Everyone in England will be able to see a GP seven days a week between 8 am and 8 pm by 2020 if the Conservative Party is elected next year, the prime minister has pledged. In an announcement at the Conservatives’ conference in Birmingham David Cameron said that £400m (€510m; $650m) would be committed over the next five years to fund the plan nationally. The initiative is currently being pilote...

Quantification of daily physical activity is of clinical interest in chronic obstructive pulmonary disease (COPD). Objective measures using activity monitors may take several days to obtain reliable results. The aim of our study was to evaluate the Stanford Seven-Day Physical Activity Recall questionnaire (PAR) against the SenseWear armband (SWA) and compare its validity with three other physic...