BACKGROUND Data from retrospective studies have suggested that there may be an interaction between fluconazole and nevirapine, increasing nevirapine concentrations and potentially leading to hepatotoxicity. METHODS This study was nested within a large double-blind placebo-controlled study designed to determine if primary prophylaxis with fluconazole (200 mg three times per week) could reduce ...

Purpose: PLX4032 (RG7204), an oncogenic BRAF kinase inhibitor undergoing clinical evaluation, has high response rates in early clinical trials in patients with advanced BRAF mutant melanoma. Combining PLX4032 with immunotherapy may allow expanding the durability of responses. The effects of PLX4032 on immune cells were studied to explore the feasibility of future combinatorial approaches with i...

Purpose: To assess the significance of Rac GTPase-activating protein 1 (RACGAP1) expression in identifying HBV-positive human hepatocellular carcinoma (HCC) patients who are at high risk for recurrent disease. Experimental Design: The prognostic significance of RACGAP1 was compared with clinicopathologic parameters available at diagnosis using multivariate and log-rank test. RACGAP1 expression ...

Because of increasing waiting times for adjuvant radiation in the province of Ontario, patients from one Canadian centre were referred to two centres in the United States. This situation provided an opportunity to compare radiation practices.We performed a retrospective review of radiation prescribed to patients following breast-conserving surgery for invasive breast cancer. Patients with posit...

Purpose: MNRP1685A is a monoclonal antibody to neuropilin-1 (NRP1). We evaluated blood-based pharmacodynamic biomarkers of MNRP1685A in two phase I studies to assess exposure/response relationships to inform target dose and regimen selection. Experimental Design: The phase I studies evaluated escalating doses ofMNRP1685A as a single agent or in combination with bevacizumab. Plasma placental gro...

Transfection of activated promotion sensitivity genes(pro genes)con fers on insensitive (P) cells susceptibifity to induction of anchorage Independent growth by tamer-promoting phorbol esters. Promotion-sen sitive (P) JB6 cell variants, from which activated pm-i and pro-2 were cloned, res@ to 12.O-tetradecanoylpborbol-13-acetate (1PA)and var Ions noophorbol tumor promoters with anchorage-Indepe...

The removal of oxidative damage from Saccharomyces cerevisiae DNA is thought to be conducted primarily through the base excision repair pathway. The Escherichia coli endonuclease III homologs Ntg1p and Ntg2p are S. cerevisiae N-glycosylase-associated apurinic/apyrimidinic (AP) lyases that recognize a wide variety of damaged pyrimidines (H. J. You, R. L. Swanson, and P. W. Doetsch, Biochemistry ...

The United States Department of Agriculture’s (USDA) National Food and Nutrient Analysis Program (NFNAP) was initiated to update existing component values and to add data on new foods and components to reflect today’s marketplace and needs for data. The USDA Nutrient Database for Standard Reference contains data for about 6040 foods for over 100 compounds. To develop a full nutrient profile for...

In the course of small angle X-ray scattering analyses K r e u t z and W e b e r 1 observed that the particles of a soluble protein preparation derived from the lamellar system of chloroplasts by treatment with formic acid, exhibited an unusual high water content of 75 per cent. Viscosimetric investigation by M e n k e and R u p p e l 2 with a preparation obtained by a somewhat modified procedu...

BACKGROUND We recently reported that treatment with intrauterine insemination and controlled ovarian stimulation (IUI-COS) did not increase ongoing pregnancy rates compared with expectant management (EM) in couples with unexplained subfertility and intermediate prognosis of natural conception. Long-term cost-effectiveness of a policy of initial EM is unknown. We investigated whether the recomme...