Despite the role of aerobic glycolysis in cancer, recent studies highlight the importance of themitochondria and biosynthetic pathways as well. PPARg coactivator 1a (PGC1a) is a key transcriptional regulator of several metabolic pathways including oxidative metabolism and lipogenesis. Initial studies suggested that PGC1a expression is reduced in tumors compared with adjacent normal tissue. Para...

OBJECTIVE To determine whether introducing a rapid test for meticillin resistant Staphylococcus aureus (MRSA) screening leads to a reduction in MRSA acquisition on hospital general wards. DESIGN Cluster randomised crossover trial. SETTING Medical, surgical, elderly care, and oncology wards of a London teaching hospital on two sites. MAIN OUTCOME MEASURE MRSA acquisition rate (proportion o...

BACKGROUND Coffee consumption has been linked to various beneficial and detrimental health effects, but data on its relation with mortality are sparse. OBJECTIVE To assess the association between coffee consumption and mortality from cardiovascular disease (CVD), cancer, and all causes during 18 years of follow-up in men and 24 years of follow-up in women. DESIGN Sex-specific Cox proportion...

Management of intraoperative fluid balance and blood conservation in adult cardiac surgery Eleftheriadis S, Stamoulis K, Ieropoulos Ch, Flossos A The reduction of homologous blood transfusions remains an important goal. The actual blood loss and the positive fluid balance during cardiac operations involving CPB result in a fall in the haematocrit and represent major risk factors for blood trans...

In human keratinocytes cultured in conditions which allow differentiation and stratification and are suitable to reconstitute a fully functional epidermis, alpha 6 beta 4 and two members of the beta 1 integrin family (alpha 2 beta 1 and alpha 3 beta 1) were respectively polarized to the basal and lateral domains of the plasmamembrane both in growing colonies and in the reconstituted epidermis. ...

Methicillin resistant Staphylococcus aureus (MRSA) is widespread worldwide in different types of animal species and as a zoonosis takes a great risk for human health not only as a food toxicoinfection, but also as a highly resistant pathogen causing serious soft tissue infectious, septicaemia and even death. One of the most affected food-producing animal species is swine in the production of wh...

Aminoglycoside antibiotics interact with seemingly unrelated families of RNA molecules. They bind to 16S ribosomal RNA and interfere with the decoding mechanism by distorting the codon-anticodon recognition.1,2 Similar aminoglycosides specifically inhibit self-splicing group I introns3 and the hammerhead ribozyme.4 Recently, these antibiotics have been found to competitively block the binding o...

This paper reports the outcomes of a longitudinal study on the CLEF Ad Hoc track in order to assess its impact in the last fifteen years on the effectiveness of monolingual, bilingual and multilingual information access and retrieval systems. 1 Motivations and Approach Experimental evaluation has been a key driver for research and innovation in the Information Retrieval (IR) field since its inc...

Many salinity gradient energy technologies such as reverse electrodialysis (RED) rely on highly selective anion transport through polymeric anion exchange membranes. While there is considerable interest in using thermolytic solutions such as ammonium bicarbonate (AmB) in RED processes for closed-loop conversion of heat energy to electricity, little is known about membrane performance in this el...

Independent mobility is an important factor affecting the health status, quality of life, and social participation of people with disabilities. Power wheelchairs have been widely used to provide independent mobility to such individuals. Despite great advancements in power wheelchairs, wheelchair related accidents occur frequently. Day-today wheelchair maneuvering often exposes wheelchair users ...