Human induced pluripotent stem cell (hiPSC)-derived keratinocytes (iKCs) have shown great potential to model monogenetic skin diseases, yet the generation of organotypic models study inflammatory diseases has not been reported. hiPSCs an infinite lifespan, can differentiate towards various types, be easily genome edited or derived from patient cells. However, iKC survival and proliferation rate...

BACKGROUND In the period 1990 to 2001, a case-control study on oral cancer and maté consumption was conducted at the Cancer Institute of Uruguay. METHODS The study included 696 newly diagnosed cases with squamous cell carcinoma and 696 controls afflicted with nonneoplastic conditions not related to tobacco smoking and alcohol drinking. The participants were matched on age and residence and th...

We generated a polyclonal antibody, 12P3, specifically recognizing rat AMPA-type glutamate receptor (GluR) subunits phosphorylated at Ser-696 of GluR2 or at the homologous sites in GluR1, GluR3, and GluR4. Using 12P3, we demonstrate that a brief exposure of a rat cerebellar slice to AMPA leads to transient phosphorylation of the GluR subunits in Purkinje cell dendrites. Persistent phosphorylati...

In the March issue of Diabetes, there is a very interesting article by Jurczak et al. (1) about glucose homeostasis and b-cell function in mice with a deletion in SGLT-2. There is also an accompanying editorial by Ferrannini (2) that is appropriately laudatory to the article but there are some extraordinary comments including, “Collectively, these findings prove that reduced SGLT-2 activity—whe...

Abstract Aim Blood tests are routinely performed as a part of pre-operative assessment (pre-op). We looked at the number group and save (G+S) samples taken pre-op compared that to patients needing blood transfusion having undergone common Urological procedures our hospital. Our objective was assess utility this invasive procedure in clinical setting. Method Data retrospectively collected from e...