BACKGROUND Atherosclerotic lesions are believed to grow via the recruitment of bone marrow-derived monocytes. Among the known murine monocyte subsets, Ly-6C(high) monocytes are inflammatory, accumulate in lesions preferentially, and differentiate. Here, we hypothesized that the bone marrow outsources the production of Ly-6C(high) monocytes during atherosclerosis. METHODS AND RESULTS Using mur...

This study presents serogroup 6 isolates from invasive pneumococcal disease (IPD) before and after the recommendation for childhood pneumococcal conjugate vaccination in Germany (July 2006). A total of 19,299 (children: 3508, adults: 15,791) isolates were serotyped. Serogroup 6 isolates accounted for 9.5% (children) and 6.7% (adults), respectively. 548 isolates had serotype 6A, 558 had serotype...

To the Editor: Streptococcus pneumoniae is a major human pathogen. In 2007, Park et al. identifi ed a novel serotype, 6C (1), which emerged from serotype 6A. A study of children in the Netherlands who had not previously received a pneumococcal vaccine found low prevalence of this newly identifi ed serotype before the heptavalent pneumococcal conjugate vaccine Prevnar/Prevenar (PCV7) (Wyeth, Tap...

We use K -band (2.1 μm) imaging to investigate the angular size and morphology of 10 6C radio galaxies, at redshifts 1 ≤ z ≤ 1.4. Two appear to be undergoing mergers, another contains two intensity peaks aligned with the radio jets, while the other seven appear consistent with being normal ellipticals in the K-band. Intrinsic half-light radii are estimated from the areas of each radio galaxy im...

The Quellung reaction has long been the standard method for pneumococcal serotyping (7); however, the new serotype 6C is reportedly indistinguishable from serotype 6A using this method (8). We report an anomalous Quellung reaction associated with serotype 6C, which may aid in diagnostic interpretation. The 7-valent pneumococcal conjugate vaccine was introduced in Australia for indigenous and ot...

We read the article of Jacobs et al. (3) with interest. The authors reported they could identify serotype 6C Streptococcus pneumoniae using factor 6d, which was developed by Statens Serum Institut, Copenhagen, Denmark. We immunized a rabbit with one serotype 6C isolate identified with a monoclonal antibody (MAb6C) in the U.S. lab in which the new type was found. Based on absorption with serotyp...

We read the papers of Bratcher and Nahm (3) and Oftadeh et al. (8) with interest. Both papers reported that Streptococcus pneumoniae serotype 6D isolates react with factor antiserum specific to serotype 6C in addition to that to 6B. Pneumococcal serotype 6C, first reported in 2007, cross-reacts serologically with serotype 6A but is differentiated by a change in the wciN gene (wciN ) among the c...

The results of Hubble Space Telescope and UKIRT imaging observations are presented for a sample of 11 6C radio galaxies with redshifts 0.85 < z < 1.5. The observations of the 6C sources reveal a variety of different features, similar to those observed around the higher power 3CR sources of similar redshifts. However, the extent and luminosity of the aligned emission appears less extreme in the ...

In this account, a detailed computational study is conducted to verify the geometric, energetic, and electronic properties of the planar cyclic (B 6C) (-2) (as the simplest carrier of hexacoordinate carbon) within some metal complexes. The [M(B 6C)] ((-)) (M = Li, Na, K) and [M(B 6C)] (M = Be, Mg, Ca) series are employed for this purpose. Relevant ab initio calculations at both DFT and post-HF ...

Although the roles of dendritic cells (DCs) in adaptive defense have been defined well, the contribution of DCs to T cell-independent innate defense and subsequent neuroimmunopathology in immune-privileged CNS upon infection with neurotropic viruses has not been completely defined. Notably, DC roles in regulating innate CD11b(+)Ly-6C(hi) monocyte functions during neuroinflammation have not yet ...