Introduction: Lidocaine is a class of Ib antiarrhythmic agent which available in various intravenous (IV) and topical forms. Systemic toxicity lidocaine has been reported following its IV injection or local infiltration for anesthesia, mostly. However, the application gel oral spray also possible. Manifestations induced systemic include neurologic cardiac symptoms. Reported cases after ingestio...

The aim of this study was to investigate the rheological behavior and mucoadhesive nature of saliva substitutes, by incorporating various mucoadhesive polymers into an artificial saliva pump spray formulation. For this purpose various mucoadhesive polymers including cellulosic polymers in the range of 0.1-1.0% and Carbomers such as C974p, C971, C934p and C971 in the range of 0.01-0.1% were adde...

The aim of this study was to investigate the rheological behavior and mucoadhesive nature of saliva substitutes, by incorporating various mucoadhesive polymers into an artificial saliva pump spray formulation. For this purpose various mucoadhesive polymers including cellulosic polymers in the range of 0.1-1.0% and Carbomers such as C974p, C971, C934p and C971 in the range of 0.01-0.1% were adde...

Eutectic Mixture of Local Anaesthetics (EMLA) is recommended for use off-label as a treatment for premature ejaculation (PE). Other topical anaesthetics are available, some of which have been evaluated against oral treatments. The purpose of this systematic review was to evaluate the evidence from randomised controlled trials (RCTs) for topical anaesthetics in the management of PE. Bibliographi...

OBJECTIVE To determine practice and attitudes of emergency physicians regarding procedural anaesthesia for nasogastric tube insertion (NGT). METHODS Survey of resident/attending emergency physicians working in a tertiary care medical centre. RESULTS Of 68 physicians, 46 responded: 98% believed that awake and alert patients find NGT insertion uncomfortable/painful; 93% used measures to reduc...

Introduction: Post-operative sore throat and cough are common complications of endotracheal intubation. These conditions may be very distressing for the patient and may lead to unpleasant memories. This study was performed in order to determine whether beclomethasone and lidocaine spray could reduce the frequency of post-operative sore throat and hoarseness after tracheal extubation.  Materials...

BACKGROUND Lidocaine is an approved local anesthetic and Class 1B antiarrhythmic with a number of ancillary properties. Our aim was to investigate lidocaine's vasoreactivity properties in intact versus denuded rat thoracic aortic rings, and the effect of inhibitors of nitric oxide (NO), prostenoids, voltage-dependent Kv and KATP channels, membrane Na+/K+ pump, and A2a and A2b receptors. METHO...

Methods: A crossover randomized study of IVRA with a forearm tourniquet was conducted on 14 male healthy volunteers. This study was performed, once using manual injection of local anesthetic and once using automatic pump injection, on two separate sessions. In both techniques, 0.3 ml/kg lidocaine 0.5% was injected over 90 seconds. The occlusion pressure, continuous venous pressure and the serum...