VB4-845 is a scFv-Pseudomonas exotoxin A fusion construct that targets epithelial cell adhesion molecule (EpCAM). A phase I trial was conducted to determine the maximum tolerated dose (MTD) of VB4-845 when administered as weekly intratumoral (IT) injections to patients with squamous cell carcinoma of the head and neck (SCCHN). Secondary objectives included the evaluation of the safety, tolerabi...

Editor Associate Editors H. Joseph Newton Christopher F. Baum, Boston College Department of Statistics Nicholas J. Cox, University of Durham Texas A & M University Joanne M. Garrett, University of North Carolina College Station, Texas 77843 Marcello Pagano, Harvard School of Public Health 979-845-3142 J. Patrick Royston, UK Medical Research Council 979-845-3142 Jeroen Weesie, Utrecht University...

1 Quaternions and the three-dimensional sphere 3 1.1 Hamiltion’s quaternions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.2 The Lie group S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.2.1 The normalizer of Q8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.3 The exponential map for S . . . . . . . . . . . . . . . . ....

PURPOSE A Phase I dose-escalation study was performed to determine the maximum tolerated dose (MTD) of the immunotoxin VB4-845 in patients with nonmuscle-invasive bladder cancer (NMIBC) refractory to or intolerant of bacillus Calmette-Guerin (BCG). Secondary objectives included evaluation of the safety, tolerability, pharmacokinetics, immunogenicity, and efficacy of VB4-845. PATIENTS AND METH...

The Influence of Competition on some Structural Features Persian Oak (Quercus brantii Lindl var.persica) Trees in Zagros Forest (Case study:Hashtad- Pahlu,Lorestan)

Mohammad Hasan Imani Nasab, Hesam Seyedin, Reza Majdzadeh, Bahareh Yazdizadeh, Masoud Salehi. Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran; Health Management and Economics Research Center, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran; Knowledge Utilization Research Center, Sch...