A mutant (MPA100) strain of Leishmania donovania was generated from a wild type (D1700) population by virtue of its ability to survive the selective pressure of gradually increasing concentrations of mycophenolic acid (MPA), an inhibitor of IMP dehydrogenase (IMPDH) activity. Comparative growth experiments revealed that the MPA100 strain was 100-fold more resistant to MPA toxicity and cross-res...

Source and Description: The DNA marker pKP 1.65, is a single copy probe for the D4S43 locus. The 1.7 kb PstI fragment reveals a VNTR (1). Recently, the detection of the VNTR by PCR, after sequencing the adjacent 1269 bp PstI fragment was described (2). In order to construct primers for PCR we have sequenced the 1652 bp PstI fragment of pKP 1.65. A guanosine rich sequence in the last third of th...

BACKGROUND Cytochrome P450 2E1 (CYP2E1), an ethanol-inducible enzyme, has been shown to metabolically activate various carcinogens, which is critical for the development and progression of cancers. It has demonstrated that CYP2E1 polymorphisms alter the transcriptional activity of the gene. However, studies on the association between CYP2E1 polymorphisms (PstI/RsaI or DraI) and gastric cancer h...

Monkey B-lymphotropic papovavirus (LPV) replicates only in B-lymphoblastoid cells, whereas the LPV mutant 76 (LPV-76) can grow in either B- or T-lymphoblastoid cells. The nucleotide sequence of the wild-type LPV PstI B segment was compared with that of LPV-76 PstI-B, within which the mutation responsible for the extended host range had been located. The VP-1 coding region of LPV-76 was found to...

Cytochrome P450IIE1 is responsible for the activation of carcinogenic N-nitrosamines, benzene, urethane, and other low-molecular-weight compounds. Restriction fragment length polymorphisms (PstI and RsaI restriction enzymes) have been identified in the cytochrome P450IIE1 transcription regulatory region that may affect expression. This study describes the PstI and RsaI polymorphisms in differen...

background: indigenous chickens could serve as precious genetic resources that should be considered in conservation and breeding programs. the major histocompatibility complex (mhc) has a strong association to disease resistance/susceptibility, production and reproduction traits in chicken. therefore, identifying its polymorphism in populations under selective breeding could be used for selecti...

Pada ruang lingkup Program Studi Teknik Informatika (PSTI) Universitas Mataram
 (UNRAM), saat ini memiliki pengatur suhu ruangan atau biasa disebut dengan Air
 Conditioner(AC) untuk menunjang kegiatan belajar mengajar namun seringkali
 penggunaannya tidak terorganisir seperti membiarkan AC tetap menyala bahkan
 setelah kelas kosong ada yang menyebabkan efisien
 dalam me...