نتایج جستجو برای: a0201
تعداد نتایج: 43 فیلتر نتایج به سال:
Genetic vaccines are emerging as a powerful modality to induce T-cell responses to target tumor associated antigens (TAA). Viral or plasmid DNA or RNA vectors harbor an expression cassette encoding the antigen of choice delivered in vivo by vaccination. In this context, immunizations with minigenes containing selected, highly antigenic, T-cell epitopes of TAAs may have several advantages relati...
MOTIVATION The binding of endogenous antigenic peptides to MHC class I molecules is an important step during the immunologic response of a host against a pathogen. Thus, various sequence- and structure-based prediction methods have been proposed for this purpose. The sequence-based methods are computationally efficient, but are hampered by the need of sufficient experimental data and do not pro...
Purpose: Interleukin 13 receptor 2-chain (IL-13R 2) has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme. Here we report the identification of a CTL epitope derived from the IL-13R 2. Experimental Design: Mature dendritic cells (DCs) were pulsed with each of the synthetic peptides that were designed, based on a binding affinity-based prediction and a prot...
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