Abstract Glioblastoma (GBM) is a WHO grade IV glioma whose heterogeneous nature and stem-like features contribute to resistance conventional chemotherapeutics. Previously, antiretrovirals have been proposed as anti-neoplastic agents, but their clinical efficacy limited. With the advent of modern anti-retroviral combinatorial therapy, we sought repurpose FDA-approved drugs for glioblastoma. Here...

In human cancers, miRNAs are important regulators of multiple cellular processes, and aberrant miRNA expression has been observed, and their alterations contribute to multiple cancer development and progression. Till now, little has been known about the role of miR-204 in human glioblastoma (GBM). In the present study, we used in-vitro assays to investigate the mechanisms of miR-204 in GBM cell...

objective: verotoxin is a member of shiga toxin family. this family contains ab protein toxins with an enzymatic (a) and a binding (b) compartment. cells that have receptor (gb3) are sensitive to cytotoxic effects of toxin. it has been shown that various tumor cells have gb3 receptor and are selectively sensitive to apoptotic effect of verotoxin. studies on tumor cell lines and laboratory anima...

objective: today, special attention is paid to the use of zirconium dioxide nanoparticle (nano-zro2), a neutral bioceramic metal, particularly for drug and gene delivery in medicine. however, there are some reports implying that use of nano-zro2 is associated with cytotoxic effects like inhibiting the cell proliferation, dna damage and apoptosis. in the present study, we examined whether nano-z...

Erucylphosphocholine (ErPC) is a promising anti-neoplastic drug for the treatment of malignant brain tumours. It exerts strong anti-cancer activity in vivo and in vitro and induces apoptosis even in chemoresistant glioma cell lines. The purpose of this study was to expand on our previous observations on the potential mechanisms of ErPC-mediated apoptosis with a focus on death receptor activatio...

BACKGROUND/AIM The tumor suppressor gene p53 is mutated in glioblastoma. We studied the relationship between the p53 gene and the biological effects of boron neutron capture therapy (BNCT). MATERIALS AND METHODS The human glioblastoma cells; A172, expressing wild-type p53, and T98G, with mutant p53, were irradiated by the Kyoto University Research Reactor (KUR). The biological effects after n...

objective: a number of studies have demonstrated the potential antitumor effects of saffron and its constituents on different malignant cells in vitro. it has been reported that a novel glycoconjugate isolated from corms and callus of saffron possesses cytotoxic activity against different tumor cellswith nitric oxide (no) production. these data suggest that the cytotoxic effect of saffron extra...

background: erythropoietin (epo) is a glycoprotein hormone function to regulate the production of red blood cells. deficiency of epo is known to cause anemia in chronically infected renal patients and they require regular blood transfusion. availability of recombinant epo has eliminated the need for blood transfusion and now it is extensively used for the treatment of anemia. glycosylation of e...

CXC ligand 10 (CXCL10) and CXCL9 are chemoattractants for activated T cells and possess angiostatic activity. Both CXCL9 and CXCL10 have been considered as important components for the anti-tumour activities of interferon-γ (IFNγ ) and interleukin12 in animal models. In this article we show that the CXCL9 and CXCL10 genes in some types of human tumour cell lines are not inducible by IFNγ and we...