Intranasal drug delivery is becoming an increasingly important form of drug administration for chronic and chronic-intermittent diseases. Important new applications currently in development include drugs for diabetes, osteoporosis, obesity, certain types of convulsive disorders, migraine headaches, symptomatic pain relief, nausea, and anxiety, among others. Transmucosal absorption across the na...

The aim of this study was to evaluate (+)-catechin and (-)-epigallocatechin gallate (EGCG) cellular uptake and transport across human intestinal Caco-2 cell monolayer in both the absence and presence of niosomal carrier in variable conditions. The effect of free drugs and drug-loaded niosomes on the growth of Caco-2 cells was studied. The effects of time, temperature, and concentration on drug ...

We have demonstrated that simple formulations composed of the parent drug in combination with generally regarded as safe (GRAS) permeability enhancers are capable of dramatically increasing the absolute bioavailability of zanamivir. This has the advantage of not requiring modification of the drug structure to promote absorption, thus reducing the regulatory challenges involved in conversion of ...

Chitosan is a versatile polysaccharide of biological origin. Due to the biocompatible and biodegradable nature of chitosan, it is intensively utilized in biomedical applications in scaffold engineering as an absorption enhancer, and for bioactive and controlled drug release. In cancer therapy, chitosan has multifaceted applications, such as assisting in gene delivery and chemotherapeutic delive...

As recommended pharmacological agents for type 2 diabetes mellitus (T2DM), Glucagon-Like Peptide 1 receptor agonist (GLP-1Ra) is highly evaluated its various beneficial effects. Among them, semaglutide (Rybelsus) has been in focus useful oral formation with hypoglycemic agent (OHA). Administration per os possible due to the developed technique of absorption enhancer sodium N-(8-[2-hydroxybenzoy...

In vitro permeation studies were done using modified Franz diffusion cell through rabbit skin and silicone membrane utilizing different ratios of oleic acid with diclofenac diethylamine (DDA) in normal saline and methanol mixture during present study. Solubility studies indicated linear increase in drug solubility with carrier concentration. The enhancing effect of all the enhancer’s ratios was...

BACKGROUND Acylation of peptide drugs with fatty acid chains has proven beneficial for prolonging systemic circulation as well as increasing enzymatic stability without disrupting biological potency. Acylation has furthermore been shown to increase interactions with the lipid membranes of mammalian cells. The extent to which such interactions hinder or benefit delivery of acylated peptide drugs...

Iron is a vital nutrient to promote the availability of tissue oxygen, cell growth and control differentiation, energy metabolism. Preventing Deficiency Anemia (IDA) necessary because iron central nervous system development especially in first years life. Iron-rich complementary foods are recommended infants around 6 months age store depleted. Better understanding absorption process factors aff...

Novel delivery technology using cell-penetrating peptides (CPPs) have recently shown their potential and are emerging as promising candidates for an oral protein and peptide delivery systems. As with for the development of any absorption enhancer that is meant to function across an epithelial layer covering a surface highly exposed to pathogens such as the intestines, concern arises about the s...