Red nail is a common disorder. However, a thorough examination of the patient's nails allows one to distinguish different diseases. For example, longitudinal erythronychia may be monodactylous or polydactylous. Only the former type can show histologically Bowen's disease or an amelanotic melanoma. Among the polydactylous type, the nosologic position of the acantholytic and dyskeratotic naevus v...

1. Department of Radiology, Jeroen Bosch Hospital, ‘s-Hertogenbosch, The Netherlands Background: A 52-year-old female, known with history of multiple sclerosis and breast carcinoma, was referred to the hospital because of knee complaints. Patient was treated with methylprednisolone for multiple sclerosis. Following treatment for keratous acanthoma, a chronic cutaneous infection developed at the...

Reflectance confocal microscopy (RCM) is an FDA approved noninvasive optical imaging technique that acquires cellular level-resolution skin images in vivo. Herein, we report a case of histopathologically proven large cell acanthoma (LCA) whose RCM features simulate those of squamous cell carcinoma in situ.

Commentary | Dermatol Pract Concept 2013;4(1):5 43 Have we really concluded what a large cell acanthoma is? Is it a distinct entity, a solar lentigo, a subtype of seborrheic keratosis, or an HPV-induced acanthoma? In 1970, large cell acanthoma (LCA) was first described by Pinkus, as a sharply demarcated, hyperkeratotic patch, often on sun-exposed skin, characterized by extraordinarily large cel...

Cornoid lamellation is a specific disorder of epidermal maturation manifested by a vertical "column" of parakeratosis and is the hallmark of porokeratosis. The cornoid lamella is characterized by a ridgelike parakeratosis. We present 11 patients with solitary lesions of a distinct pattern of cornoid lamellation. The mean age at presentation clinically was 57 years; there were 9 men and 2 women....