The physicochemical constitution of DNA cannot warrant lifelong stability. Yet, unlike all other macromolecules, nuclear DNA must last the lifetime of a cell ensuring that its vital genetic information is preserved and faithfully transmitted to progeny. An increasing body of evidence suggests that progressive genome instability likely contributes to aging and shortens lifespan. In support, defe...

programmed, then this implies that definite molecular alterations on the level of transcription or translation should be observable, and furthermore, it should be possible (theoretically at least) to accelerate, decelerate, or even reverse these events by the appropriate manipulation of molecular events. Furthermore, we would expect that naturally-occurring mutations may occasionally hit upon s...

Assessment of biomarkers that reflect objective indicators of physiological processes has become increasingly popular in psychological research on stress and aging. The current article reviews biomarkers of the neuroendocrine and immune systems, including issues related to measurement and normative age-related changes. We also discuss how exposure to stressors can provoke changes in these bioma...

When Overexposure to sun UV radiation leads skin damage and increases the risk of cancer; thus, it is a factor in aging, which accelerate aging cancer. To determine Photoprotective potential was evaluated by biomechanical measurements tissue histopathological examination skin. Showed The group irradiated with exposed for 4 h (UV lamps, wavelength 365 nm, power 6 W) without Aloe vera showed sign...

Successful aging encompasses more than just the prevention of disease and disability; the truly well-lived life is demonstrated by a sense of vitality and independence, freedom from bodily pain, and the continued involvement in meaningful activities. While physical inactivity and sedentary behaviors accelerate the aging process, deliberate exercise and other forms of activity delay and/or preve...

In order to accelerate the growth of interfacial intermetallic compound (IMC) layers in a soldering structure, Cu/SAC305/Cu was first ultrasonically spot soldered and then subjected to isothermal aging. Relatively short vibration times, i.e., 400 ms and 800 ms, were used for the ultrasonic soldering. The isothermal aging was conducted at 150 °C for 0, 120, 240, and 360 h. The evolution of micro...

Population aging is accelerating worldwide, straining the global economy and health services. Cellular senescence a significant contributor to various age-related neurological neuropsychiatric disorders, including Alzheimer’s disease Parkinson’s disease. Some external factors, such as exposure ionizing radiation, can accelerate aging. In recent years, it has become known that post-transcription...