The X-ray crystal structure of carbamoyl phosphate synthetase (CPS) from Escherichia coli revealed the existence of a molecular tunnel that has been proposed to facilitate the translocation of reaction intermediates between remotely located active sites. Five highly conserved glutamate residues, including Glu-25, Glu-383, Glu-577, Glu-604, and Glu-916, are close together in two clusters in the ...

The purpose of this study is to ensure the safety operation and maintenance utility tunnel. First all, framework management system in phase tunnel constructed by combining BMI technology, Access database tool integrates data with BIM technology establish a BIM-based database. On basis, model an using Autodesk Revit modeling software. Finally, application visualization, education fire simulation...

The TolC channel-tunnel spans the bacterial outer membrane and periplasm, providing a large exit duct for protein export and multidrug efflux when recruited by substrate-engaged inner membrane complexes. The sole constriction in the single pore of the homotrimeric TolC is the periplasmic tunnel entrance, which in its resting configuration is closed by dense packing of the 12 tunnel-forming alph...

There are several industrial methods for tunnel ventilation system design. In particular, for tunnels where axial flow fans are applicable, there are specialized computer programs that calculate the various pressure drops that consider wall friction and local losses due to signs and appurtenances, and considering vehicle emission factors based on up-hill or down-hill conditions, determine the n...

The Konjsko tunnel is an integral part of the Zagreb-Split-Dubrovnik highway, section Prgomet-Dugopolje. It consists of two tunnel tubes having 1326.0 and 1133.8 meters in length. The greatest overburden amounts to 150 m. This paper presents geotechnical measurement results and back numerical analyses. Back numerical analyses in combination with geotechnical measurements enable safer and more r...

There has been booming interest in natural orifice transluminal surgery since it was first described. Several techniques first developed for the safe transluminal access now derive into independent endoscopic surgical procedures. In this paper, we describe a case treated by a novel procedure by submucosal tunnelling technique and provide a literature review of the rise of tunnel endoscopic surg...

(1) Tunnel HA MH Mobile Internet users expect access to the services and applications that are available in wired networks. Consequently, many efforts are being made to provide efficient mobility and multicasting support, and to bring the two together in the next generation of IP networks.