A flexible non-enzymatic electrochemical sensor based on a braided copper cobaltite/MWCNT composite capable of detecting acetylcholine at sub-nanomolar level was developed to monitor released by human neural cells.

Cortical release of acetylcholine was assayed using the leech muscle preparation in cats with transected brainstems. Both spontaneous and elicited somatosensory and visual cortical release of acetylcholine were measured, photic stimuli being directed into both eyes of midpontine-pretrigeminal and prepontine preparations. Animals with midpontine transections had a higher spontaneous release of a...

up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (m1, m2, m3 and m4). in our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. isolated preparations of longitudinal and circular muscle layers from human stomach were used. acetylcholine, bethanechol, carbachol, pilocarpine and ahr -602 produced concentrati...

Acetylcholine is the major excitatory neurotransmitter at nematode neuromuscular junctions, and more than a third of the cells in the C. elegans nervous system release acetylcholine. Through a combination of forward genetics, drug-resistance selections, and genomic analysis, mutants have been identified for all of the steps specifically required for cholinergic function. These include two enzym...

This article traces the development of knowledge about the physiology and pharmacology of acetylcholine and its receptors between 1930 and 2005, with emphasis on contributions by members of the British Pharmacological Society, and by other British pharmacologists and physiologists.