When incubated in acidified serum, the erythrocytes of paroxysmal nocturnal hemoglobinuria (PNH) are hemolyzed through activation of the alternative pathway of complement (APC), but normal erythrocytes are resistant to this process. PNH cells are deficient in decay-accelerating factor (DAF), a complement regulatory protein that inhibits the activity of both the classical and the alternative pat...

objective(s) several lines of evidence indicate that neuropeptides exhibit protective properties against gastroduodenal ulcers. neurotensin, a gut-brain neuropeptide, is implicated in a number of physiological processes in the central nervous system and peripheral tissues including gastrointestinal tract. in the present study, we aimed to investigate the gastroprotective potential of either per...

Abstract Hexanal and salicylaldehyde are naturally-occurring antimicrobial volatiles from edible plants known for their efficacy post-harvest preservation of fruits vegetables. Due to volatility susceptibility oxidation, these must be encapsulated within a carrier control release, especially when applied in modified atmnosphere active packaging applications. In this study, precursor (SP; 1,3-di...

Human telomerase reverse transcriptase (hTERT) is upregulated in most cancer cell types as well in immortalized cells. The underlying mechanism for such upregulation, however, remains largely unknown. We report here that bile acids under acidified media increase hTERT expression via c-myc activation in primary human gastric cancer cell lines. Human gastric cancer MKN28, MGC803 and SGC7901 cells...

We propose an efficient method to synthesize large-scale soluble acidified graphitic carbon nitride (g-C3N4). The as-prepared material exhibits the characteristics of a poly-ammonium salt and is soluble in several solvents with good dissolution-recrystallization reversible equilibrium. The pH value- and temperature-dependent solubility of the acidified g-C3N4 facilitates its separation and puri...

Acidification of the cytosol of a number of different cell lines strongly reduced the endocytic uptake of transferrin and epidermal growth factor. The number of transferrin binding sites at the cell surface was increased in acidified cells. Electron microscopic studies showed that the number of coated pits at the cell surface was not reduced in cells with acidified cytosol. Experiments with tra...

Objective(s) Several lines of evidence indicate that neuropeptides exhibit protective properties against gastroduodenal ulcers. Neurotensin, a gut-brain neuropeptide, is implicated in a number of physiological processes in the central nervous system and peripheral tissues including gastrointestinal tract. In the present study, we aimed to investigate the gastroprotective potential of either p...

In this study, we examined the effects of formic acid administration to the drinking water on performance, intestinal microflora and carcass contamination in male broilers. A total of 312 day-old male broiler chicks were allocated to two groups with three replicates. The first group (control) received normal drinking water (pH 7.4) during the experiment. The second group consumed acidified drin...