resistin (retn), recently found to be relevant to inflammation and inflammatory disorders. we, therefore, aimed to investigate the potential role of retn gene polymorphism in pathogenesis of acne vulgaris with familial history. we investigated the retn-420c/g polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. in this study, we als...

Acne vulgaris is one of the most prevalent inflammatory skin conditions found in late childhood and adolescence. Despite various studies, the etiology or pathogenesis of acne is still not well understood and a single, primary cause has not been identified. In the past several decades, various studies have indicated that patients with acne are under increased cutaneous and systemic oxidative str...

Background. Acne vulgaris is a common skin disease that can adversely affect the quality of life of patients. Objective. The aim of this study was to determine the quality of life in patients with acne vulgaris. Methods. This study was carried out on 70 patients with acne vulgaris (28 males, 42 females). All the patients filled out two Persian versions of questionnaires: short form 36 (SF-36) a...

Acne is the most common disease treated by dermatologists based upon data from the 1996 U.S. Census. The lifetime prevalence of acne approaches 90%. Acne vulgaris is a chronic disease with the highest prevalence in adolescents. The onset of acne vulgaris occurs during the onset of puberty, which is at a younger chronological age in females than in males. Both females and males have acne that ex...

INTRODUCTION Acne vulgaris is a pilosebaceous gland disease that usually affects people from puberty to young adulthood. It is seen especially on the face, neck, trunk and arms. Its severity differs from patient to patient and its pathogenesis is multifactorial. The main pathogenic factors of acne are high sebaceous gland secretion, follicular hyperproliferation, high androgen effects, propioni...

BACKGROUND Due to increasing interest from acne patients concerned about the side effects associated with conventional therapies, complementary and alternative medicine (CAM) has been suggested as a new therapeutic modality for acne vulgaris. Herbal medicine is one of these CAM treatments. Cheongsangbangpoong-tang (CBT) is a common herbal formula used in patients with acne vulgaris in the clini...

OBJECTIVE To evaluate effectiveness of 2% tea lotion in comparison with 5% zinc sulphate solution in the treatment of acne vulgaris. METHODS This is a single-blind randomly comparative therapeutic clinical trial carried out in the Department of Dermatology, Baghdad Teaching Hospital, Baghdad, Iraq from June 2006 to December 2007. Full history and clinical examination were studied for each pat...

BACKGROUND Tazarotene foam is the first topical retinoid foam approved for the treatment of acne vulgaris. OBJECTIVE To review the safety and efficacy studies of tazarotene foam in the treatment of moderate to severe acne. METHODS Five Phase I safety studies in normal controls are reviewed and two Phase III safety and efficacy studies in patients with moderate to severe acne are reviewed. ...

Dapsone 7.5% gel (Aczone®) is indicated for the once-daily topical treatment of acne vulgaris in patients aged ≥12 years. Dapsone is a sulfone antibacterial with anti-inflammatory actions, which are thought to be largely responsible for its efficacy in treating acne vulgaris. In two phase III trials of 12 weeks' duration in patients aged ≥12 years with moderate acne vulgaris, once-daily dapsone...

Acne is one of the most common dermatological diseases, and obsessive compulsive disorder is among the most frequent psychiatric conditions seen in dermatology clinics. Comorbidity of these conditions may therefore be expected. The aim of this study was to measure obsessive compulsive symptoms and quality of life in patients with acne vulgaris, compare them with those of healthy control subject...