Success in developing novel therapies to recommence self-tolerance in autoimmunity depends on the induction of T regulatory (Tr) cells. Here, we report that rapamycin combined with interleukin (IL)-10 efficiently blocks type 1 diabetes development and induces long-term immunotolerance in the absence of chronic immunosuppression in nonobese diabetic (NOD) mice. Rapamycin mediates accumulation in...

The presence of disease during pregnancy leads to alteration in the normal function of other system. It is important to treat the disease depending upon the severity and type of urgency. The management of several diseases in pregnancy has been reported earlier but it is necessary to report a rare pathology, treatment option and its anaesthetic management [1]. Spinal tumors although being rare i...

Mammalian TBP consists of a 180 amino acid core that is common to all eukaryotes, fused to a vertebrate-specific N-terminal domain. We generated mice having a modified tbp allele, tbp(DeltaN), that produces a version of TBP lacking 111 of the 135 vertebrate-specific amino acids. Most tbp(DeltaN/DeltaN) fetuses (>90%) died in midgestation from an apparent defect in the placenta. tbp(DeltaN/Delta...

Unilateral nevoid telangiectasia syndrome (UNTS) can be classified into two major categories: congenital and acquired. There have been reports showing an increase in skin estrogen and progesterone receptors in patients with this syndrome. We report a male patient with acquired unilateral nevoid telangiectasia syndrome without any associated physiological or pathological conditions.<...

conclusions the results indicate a rapid increase in the number of hiv/aids cases in east azerbaijan, necessitating immediate attention and strategies to combat the rapid spread of the disease. development of provincial and national hiv/aids strategies demands more accurate and comprehensive hiv/aids surveillance. background this study was performed in response to the rapid propagation of hiv/a...