The US Food and Drug Administration (FDA) has recently suggested that the bioequivalence (BE) for products of drugs with narrow therapeutic indices (NTI) be assessed by the approach of reference-scaled average BE (SABE). Subsequently, in December, 2012, the FDA issued draft guidances for the comparison of products of warfarin sodium and of tacrolimus. The guidances expect that 4-period studies ...

this study aimed to examine key factors affecting rural female facilitators’ role in participatory rural development in tehran province. since the researchers intended to have a better insight into the facilitators’ role and employ inquiry as a learning forum for bringing about changes for all participants, they preferred to use a case study based upon an appreciative inquiry method. the study ...

The past years have witnessed great progress on remote sensing (RS) image interpretation and its wide applications. With RS images becoming more accessible than ever before, there is an increasing demand for the automatic of these images. In this context, benchmark datasets serve as essential prerequisites developing testing intelligent algorithms. After reviewing existing in research community...

In the current study with using of 553 questionnaires, knowledge of Kerman small pistachio growers regarding hygienic pistachio production especially aflatoxin was investigated. The results showed that factors such as high density of pistachio trees in the orchards and limited water resources are the main factors of creating potential of aflatoxin contamination in pistachio. These factors are n...

The Food and Drug Administration (FDA) Critical Path Initiative as well as the European Medicines Agency Road Map to 2010 (ref. 2) call for opportunities for more efficient drug development. One of the initiatives that has emerged in this context is the elaboration through guidance of exploratory investigational new drugs (INDs)/clinical trial applications (CTAs). This article reviews the histo...