In acute promyelocytic leukemia, granulocytic differentiation is arrested at the promyelocyte stage. The variant t(11;17) translocation produces two fusion proteins, promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα) and RARα-PLZF, both of which participate in leukemia development. Here we provide evidence that the activity of CCAAT/enhancer binding protein α (C/EBPα), a ma...

homogeneously staining regions (hsr) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplifi cation in a variety of cancers. the diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. this study report two cases, one with acute myeloblastic leu...

0

purpose: to report a case of acute myelogenous leukemia (aml) presenting with periorbital cellulitis and progressing to facial and neck cellulitis. case report: a 17 year old male patient presented with periorbital cellulitis which progressed to the right hemifacial and neck area. he did not respond to regular antibiotic therapy. peripheral blood smear showed leukocytosis with predominance of i...

background: treatment of cancer patients using conventional chemotherapy causes serious side effects and, at best, merely extends the patient’s lifespan by a few years. the potential of alternative therapies may therefore be of great benefit in cancer control. the effect of trigonella foenum graecum seed extract has been previously reported on some neoplastic cells. here, its effect is evaluate...

introduction: acute leukemia covers a broad spectrum of hematological clonal diseases originating from the malignant transformation of stem cells. current chemotherapeutic methods result in an incomplete response to primary regimens in 30-40% of cases. methods: 20 patients who had been diagnosed with acute leukemia and who had displayed defined criteria in order to enter our study, were assesse...

hypercalcemia in children is a medical emergency and often manifests as nonspecific symptoms such as nausea, vomiting, weight loss, and anorexia. severe hypercalcemia is a rare complication of malignancy in children, while it can be seen in various types of malignant tumors. it is usually associated with significant morbidity and may be severe enough to threaten life. incidence of hypercalcemia...

abstract objective fever and neutropenia are a common complication of chemotherapy in cancer. it is usually managed by hospitalization and empiric administration of antibiotics. use of fluroquinolones is limited because of joint/cartilage toxicity. this study attempted to compare the efficacy of oral ciprofloxacin with intravenous ceftazidim in low risk febrile neutropenic lymphocytic leukemia....

background: interaction between killer cell immunoglobulin-like receptors (kir) and human leukocyte antigen (hla) class i molecules is important for regulation of natural killer (nk) cell function. objective: the aim of this study was to investigate the impact of compound kir-hla genotype on susceptibility to acute leukemia. methods: cohorts of iranian patients with acute myeloid leukemia (aml;...

endocarditis due to aspergillus infection is a rare complication in patients with hematological malignancies. here, we present a case of aspergillus endocarditis in a patient with acute myeloid leukemia (aml) successfully treated with antifungal therapy and surgical treatment. the patient was a 51 years old male, a known case of aml who was admitted to our medical center for evacuating his valv...