Dimethyl sulfoxide (DMSO) is a well-known hydroxyl radical scavenger, which is readily absorbed through biological membranes. We studied the effects of locally applied DMSO on acute spinal cord injury. Either 10% DMSO in saline (n=8) or saline alone (n=7) was applied directly to the exposed cervical spinal cord of rats 1 hour after clip compression injury of 26 g force for 1 minute. The outcome...

This article deals with the respiratory management of acute spinal cord injury patients discussing the mechanics of respiration, assessment and management strategies, respiratory care in the acute stage, invasive mechanical ventilation and weaning including survival following spinal cord injury. The importance of the care in supine position, physiological instability of the injured cord effect ...

it was estimated that 3 million people suffered from spinal cord injury. unfortunately up to date, there are not any reliable clinical treatments for spinal cord injury and researches for treatments of sci have focused on medication, surgery, stem cell transplantation, molecular therapy and tissue engineering. also scientists are trying to use a combination of stem cells and nanotechnology scie...

conclusions this study demonstrated that most victims of csfx in our region are 16 to 40 years of age. a male predominance was observed, and motor vehicle collisions were the most frequent trauma mechanism leading to cervical spine injury (mostly due to car rollover accidents), with falls as the second most frequent. the rate of sci in our study was 3.62% of all cases and the mortality rate was...

Spinal cord injury (SCI) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms. Neuroinflammation is an important secondary injury process in SCI. The local inflammatory microenvironment within the injured spinal cord ...

background: spinal cord injury (sci) occurs most often to young men at the peak of their reproductive health. only 10% of sci men can father children without medical assistance due to potential impairments in ejaculation and sperm quality. objective: the main objective of this experimental study was to evaluate the epididymal necrospermia- sperm death, after chronic sci in rat. materials and me...

spinal cord injury (sci) leads to a significant health problem associated with a broad range of secondary complications and disabilities. in this regard, animal models can help us to understand the pathobiology of sci and evaluate the effects of potential treatments for sci. in contusion models of sci, different devices including surgical spring-loaded clips, balloons, forceps, weights and the ...

prevalence of spinal cord injury (sci) in iran is considerable and developing a national registry is substantial. registry can be a foundation of efforts for patient care improvement, clinical research facilitation, preventative strategy formulation and policymaking for better support of patients. with respect to long-term and multiple consequents of the lesions that will have a negative impact...

the pathology of spinal cord injury (sci) comprises multiple processes characterized by extensive cell death and glial scar formation, which together limits axonal regeneration. in particular, variations in chronic demyelination of the lesion have been found to be largely independent of injury intensity, suggesting a secondary pathologic origin. this chronic demyelination results in progressive...