Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system (CNS) characterised by encephalopathy and other neurological manifestations. ADEM is a heterogeneous syndrome predominantly found in the paediatric population. ADEM usually takes a monophasic course, but some patients have a relapsing disease. Patients diagnosed with ADEM have mult...

AIMS Brighton Collaboration (BC) case definitions are independent from presumed causes or triggers, hence should be applicable in routine clinical settings. SCOPE 255 cases with discharge diagnoses of aseptic meningitis (ASM; n=164), encephalitis (ENC; n=48), myelitis (MYE; n=8), ADEM (n=10), or bacterial meningitis (BM; n=59; control group) were tested against the BC case definitions ASM, EN...

BACKGROUND AND PURPOSE Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disorder that predominantly affects children. Previous studies have mostly involved children in Western developed countries. METHODS This study retrospectively reviewed the clinical profiles of ADEM in adult Chinese patients. RESULTS ADEM occurred during summer and autumn in about two-thirds ...

We present a case of a boy who developed obsessive-compulsive disorder (OCD) shortly after an episode of acute disseminated encephalomyelitis (ADEM). To our knowledge, this is the first report of the development of OCD in a child who has had ADEM. This presentation is consistent with our understanding of OCD as a complex genetic disease involving the cerebral white matter tracts, and may indica...

Acute disseminated encephalomyelitis (ADEM) is an acute or subacute condition characterized by widespread multifocal neurological deficits of variable severity. We report a case of a 45-year-old man with ADEM following anti-rabies vaccine (ARV).

INTRODUCTION Spontaneous reporting of adverse drug reactions (ADRs) is used for continuous risk-benefit evaluation of marketed pharmaceutical products and for signal detection. The Adverse Drug Event Manager (ADEM) is a service offered to clinicians employed at hospitals in the Capital Region of Denmark. The ADEM assists healthcare professionals in reporting suspected ADRs to the Danish Health ...

BACKGROUND Fever of unknown origin (FUO) can be defined as a body temperature higher than 38.3°C on several occasions over more than 3 weeks, the diagnosis of which remains uncertain after 1 week of evaluation. Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system with a wide range of clinical manifestations. The highest incidence of ...

Myelin oligodendrocyte glycoprotein (MOG) is a candidate target antigen in demyelinating central nervous system diseases, including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica, and multiple sclerosis. It may give prognostic information regarding monophasic or recurrent course of the disease. MOG antibodies have been shown to be positive in high titers during the first epis...