To investigate the role of telomerase in the multistep colorectal carcinogenesis, we examined telomerase activity in 31 adenomatous polyps and 22 paired cancer-normal mucosa specimens from non-hereditary nonpolyposis colorectal cancer patients. Telomerase activity was detected in 18% of normal mucosa, 16% of small (<1.0 cm) polyps, 20% of intermediate polyps, 71% of large (>2.0 cm) polyps, and ...

BACKGROUND In Western countries, colonic polyps are usually adenomatous in nature, are evenly distributed along the entire colon in asymptomatic per-sons and show a left-sided predominance in symptomatic patients. There is dearth of such literature from India. METHODS We retrospectively analyzed reports of colonoscopies done in our institution during the period 2001 to 2005. Clinical features...

34 children aged 9 months to 12 years presenting with chronic and intermittent rectal bleeding were diagnosed as having colorectal polyps by fiberoptic colonoscopy performed under sedation. Bleeding per rectum (mean duration, 15 months) was the chief presenting symptom and was present in 97% of these patients. In 85% of patients polypectomy was carried out without using general anesthesia....

From June 1989, to June 1991, 58 patients with GI polyps were reviewed. Except two patients who had multiple polyps, 56 had only one polyp. The size of polyps were 0.5 to 3 em in diameter. 51 (75%) of polyps were located in the rectosigmoid region, 25 (37%) were in the rectum and 26 (38%) in the sigmoid. (Seventeen) (25%) polyps (two in right colon, four in transverse, and 11 in descending...

Objective: This study was carried out to evaluate the frequency, of polypoid lesions of the gastrointestinal tract and to observe the frequency of dysplastic / malignant change in these polyps. Design: This was a 13-years retrospective study. Setting: Department of Pathology, Basic Medical Sciences Institute (BMSI), JPMC Karachi and included all polypoid lesions from the attached hospital, Paki...

A 30-year-old female, with no significant family history, came with complaints of intermittent, colicky abdominal pain and abdominal distension of 5 months duration, with significant weight loss. CT abdomen showed multiple polypoidal lesions in the colon. Colonoscopy revealed multiple polyps carpeting the entire colon (Fig. 1A); biopsy of which revealed adenomatous polyps. The patient underwent...

Lactoferrin (LF), a secreted, iron binding glycoprotein originally discovered as a component of milk, is found in a variety of exocrine secretions and in the secondary granules of polymorphonuclear leukocytes. Animal experiments have shown that oral administration of bovine lactoferrin (bLF) exerts anticarcinogenesis effects in the colon and other organs of the rat. The aim of this study was to...

aim : the aim of this study was to report the anatomical location and histologic type of colorectal polyps in a large series of iranian patients that attended for colonoscopy. background : polyps that develop through the adenoma-carcinoma pathway are considered neoplastic and may eventually progress to invasive carcinomas. in addition polyps can develop with no neoplastic potential. these neopl...

Colorectal adenomas and possibly some hyperplastic polyps are precursors of colorectal cancer. Tobacco use is associated in epidemiologic studies with these polyps, although links between smoking and colorectal cancer are less consistent. To characterize the role of tobacco in early colorectal carcinogenesis, we compared tobacco use among 4,383 subjects with histologically verified benign (hype...

Lactoferrin (LF), a secreted, iron binding glycoprotein originally discovered as a component of milk, is found in a variety of exocrine secretions and in the secondary granules of polymorphonuclear leukocytes. Animal experiments have shown that oral administration of bovine lactoferrin (bLF) exerts anticarcinogenesis effects in the colon and other organs of the rat. The aim of this study was to...