Primary aldosteronism is the most common secondary endocrine form of hypertension and causes many cardiovascular injuries. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma. However, their impacts on left ventricular remodeling precluding interference age, sex, blood pressure are still uncertain. We enrolled 184 adenoma patients who received adrenalectomy. C...

The relatively new operation of laparoscopic adrenalectomy has now become the procedure of choice for the management of most benign adrenal tumours. We have reviewed the data relating to the first 25 patients on whom we performed laparoscopic adrenalectomy and have made comparison with a group of 25 diagnosis-matched individuals on whom we had previously carried out open adrenalectomy. The pati...

It has previously been shown that expression of memory of maze-learning in mice is blocked by puromycin injected intracerebrally one or more days after the training experience. Bilateral adrenalectomy before training has now been found to protect memory against the effects of puromycin. This protection is absent when adrenalectomy follows training. In view of control experiments, we conclude th...

OBJECTIVES Laparoscopic adrenalectomy has become the standard of care for resection of adrenal masses, with extremely low morbidity and mortality. This study investigates the difference in outcomes in patients who underwent laparoscopic adrenalectomy, comparing obese with healthy weight patients. METHODS A retrospective chart review was performed on patients undergoing laparoscopic adrenalec...

abstract adrenal gland cysts are rare indications of adrenal diseases, which are commonly asymptomatic. in radiological studies, these cysts, known as incidentalomas, are often detected by coincidence accounting for 6% of the population. adrenal incidentalomas are commonly detected, and autonomous cortisol hypersecretion is the most prevalent abnormality associated with these masses. since this...

After adrenalectomy, the plasma levels of adrenocorticotropic hormone (corticotropin, ACTH)/endorphin peptides in rats rise dramatically in the first 4 hr while pituitary peptide levels fall sharply. Eight hours after adrenalectomy, plasma levels are near control values again but they then increase continuously over the next 8 days. Proopiomelanocortin (POMC) mRNA levels in the anterior pituita...

Aim to determine the optimal tactics for examination and treatment of patients with macronadular bilateral adrenal hyperplasia.
 Material methods. The study included 11 macronodular hyperplasia (main group). To compare biochemical parameters, results 26 healthy people were studied (control group).
 Results. characterized by deficiency 11-hydroxylase, 21-hydroxylase, 11-hydroxysteroid ...

Cushing's syndrome requires glucocorticoid replacement following adrenalectomy. Based on a simplified glucocorticoid therapy scheme and the peri-operative observation, we investigated its efficacy and safety up to 6 months post-adrenalectomy in this cohort study. We found the adrenocorticotropic hormone (ACTH) levels were normal post-adrenalectomy, and sufficient to stimulate the recovery of th...

The current standard of care for treating benign adrenal disease is laparoscopic adrenalectomy. Surgical tools, such as ultrasonic shears and vessel sealing systems, have increased in popularity and improved surgical outcomes. However, the safety profile of clipless and sutureless adrenalectomy has not been completely established. We report on a complicated 74-year-old male who underwent signif...

Adrenal tumors require careful clinical and biochemical evaluation with appropriate imaging to determine malignancy or functional status. Tumors that are suspicious or confirmed for malignancy or hormone-secreting require adrenalectomy. This review discusses adrenal gland anatomy, physiology, and pathology, indications for adrenalectomy, preoperative management, and an update on surgical approa...