Stress can trigger the relapse of drug use in recovering cocaine addicts and reinstatement in rodent models through mechanisms that may involve norepinephrine release and β-adrenergic receptor activation. The present study examined the role of β-adrenergic receptor subtypes in the stressor-induced reinstatement of extinguished cocaine-induced (15 mg/kg i.p.) conditioned place preference in mice...

Both a(vasoconstrictor) and (3(vasodilator) receptor activity was demonstrated in the coronary arteries of the unanesthetized dog independent of adrenergic receptors in the myocardium. In the y3-receptor blocked animal, a-adrenergic receptor activity was demonstrated after intravenous and intracoronary injections of epinephrine and norepinephrine by the occurrence of coronary vasoconstriction w...

I N 1964 Oj-adrenergic receptors were first described pharmacologically using the in vitro melanocyte granule dispersion technique in Rana pipiens. The goal of these studies was to assess the intrinsic activity on o^-adrenergic receptors of methyldopa's neurotransmitter metabolites and other catecholamines. Publication of this description was delayed for 13 years, 1 until the evidence for a rec...

BNST: bed nucleus of the stria terminalis; CRF: corticotropin releasing factor; VTA: ventral tegmental area Recommended journal section: Neuropharmacology This article has not been copyedited and formatted. The final version may differ from this version. ABSTRACT Stress can trigger relapse of drug use in recovering cocaine addicts and reinstatement in rodent models through mechanisms that appea...

I N 1964 Oj-adrenergic receptors were first described pharmacologically using the in vitro melanocyte granule dispersion technique in Rana pipiens. The goal of these studies was to assess the intrinsic activity on o^-adrenergic receptors of methyldopa's neurotransmitter metabolites and other catecholamines. Publication of this description was delayed for 13 years, 1 until the evidence for a rec...

OBJECTIVE Significant cardiac dysfunction after brain death leading to exclusion from procurement for cardiac transplantation is seen in up to 25% of potential organ donors in the absence of structural heart disease. The cause includes uncoupling of the myocardial beta-adrenergic receptor signaling system. The mechanism, however, has not yet been described. This study investigates our hypothesi...

β-adrenergic receptor blockade has been demonstrated to benefit individuals with autism. Genetic studies have identified numerous factors linking β-adrenergic receptor blockade to autism spectrum disorder (ASD), including βadrenergic receptor variants, human leukocyte antigen genes, apoptotics factor caspase-3, glycogen synthetase kinase-3β, and the reduced form of nicotinamide adenine dinucleo...

There is considerable evidence from our lab and others for a functional link between β-adrenergic receptor and insulin receptor signaling pathways in retina. Furthermore, we hypothesize that this link may contribute to lesions similar to diabetic retinopathy in that the loss of adrenergic input observed in diabetic retinopathy may disrupt normal anti-apoptotic insulin signaling, leading to reti...

OBJECTIVE Abrupt increases in right ventricular afterload occur after cardiac transplantation and pulmonary artery banding, which can result in right ventricular hypertrophy and dilatation. Right ventricular dysfunction is also accompanied by beta-adrenergic receptor desensitization. We sought to determine whether selective right ventricular expression of a transgene encoding a beta-adrenergic ...

The effects of epidermal growth factor (EGF) on the beta-adrenergic receptor-coupled adenylyl cyclase system were studied in a human salivary cell line (HSY). The beta-adrenergic agonist isoproterenol (10(-5) M) stimulated adenylyl cyclase activity by approximately 2-fold, and the isoproterenol response was increased 1.8-fold after prolonged (48 h) exposure to EGF (5 x 10(-10) M). In contrast, ...