RATIONALE Aeroallergen sensitization and virus-induced wheezing are risk factors for asthma development during early childhood, but the temporal developmental sequence between them is incompletely understood. OBJECTIVE To define the developmental relationship between aeroallergen sensitization and virus-induced wheezing. METHODS A total of 285 children at high risk for allergic disease and ...

aeroallergens continue to have a key role in the pathogenesis of asthma and allergic diseases and have recently received increased attention in medical research throughout the world. the prevalence of aeroallergens vary in different regions, depending on the type of climate. the aim of the present study was to determine prevalence of the sensitivity to aeroallergens among patients with asthma a...

BACKGROUND Nasal eosinophils are a biomarker for allergic rhinitis (AR) and are associated with increased symptom severity. OBJECTIVE To identify predictors of allergic eosinophilic rhinitis (AER) in early childhood in children at higher risk for chronic allergic respiratory disorders. METHODS In the Cincinnati Childhood Allergy and Air Pollution Study, infants born to aeroallergen-sensitiz...

The rising incidence of allergic disorders in developed countries is unexplained. Exposure to traffic related air pollutants may be an important cause of wheezing and asthma in childhood. Experimental evidence from human studies suggests that diesel exhaust particles, constituents of fine particulate matter less than 2.5 microns (PM(2.5)), may act to enhance IgE mediated aeroallergen sensitizat...