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Age-related macular degeneration (AMD) is a leading cause of blindness among Caucasians in various countries.1-3 In addition, cases of AMD are increasing among non-Caucasians, and AMD has become one of the major causes of blindness worldwide. To address this problem, several etiological, pathological, and basic science studies are being conducted. Etiological studies have revealed that the risk...

This functional magnetic resonance imaging study presented participants with a face and scene simultaneously on each trial, and assessed the impact of perceptual versus reflective selective attention on activity in parahippocampal place area. Young and older adults showed equivalent activation in parahippocampal place area when cued to attend to the scene when the stimuli were perceptually pres...

In many applications, covariates possess a grouping structure that can be incorporated into the analysis to select important groups as well as important members of those groups. This work focuses on the incorporation of grouping structure into penalized regression. We investigate the previously proposed group lasso and group bridge penalties as well as a novel method, group MCP, introducing a f...

Clinical measurements by the increment-threshold technique of W.S. Stiles are reported in five cases of age-related macular degeneration. Measurements were made on a modified Tübingen perimeter using 1 degree, short-wavelength targets presented on a red field.

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries. The role of complement in the development of AMD is now well-established. While some studies show evidence of complement dysregulation within the eye, others have demonstrated elevated systemic complement activation in association with AMD. It is unclear which one is the primary driver ...

BACKGROUND The pathogenesis of age-related macular degeneration (AMD) remains unknown. Genetic and environmental factors are thought to be associated with AMD. Although some studies have reported familial cases of AMD in the United States, as far as we know, familial cases of AMD have rarely been reported in Japan. CASES We describe three families with two members of each family affected with...