INTRODUCTION Osteoblastoma is an uncommon benign bone tumor that accounts for 1 percent of all primary bone tumors. About 30 to 40 percent of all osteoblastoma cases involve the spine. Osteoblastoma involving the nasal cavity is rare, with only 11 reported cases in the English-language literature, while only four cases of turbinate osteoblastoma have been described. CASE PRESENTATION We repor...

OBJECTIVE To investigate the biological behavior of classical and atypical osteoblastomas in comparison to osteosarcomas. METHODS Based on histological parameters, 30 osteoblastomas were subclassified as classical osteoblastomas (23/30) or atypical osteoblastoma (high cellularity, prominent blue osteoid, and epithelioid osteoblasts--7/30). Comparative immunohistochemical and clinical analysis...

Benign osteoblastoma refers to a benign tumor of the bone. Osteoblastoma most commonly affects the vertebrae and long tubular bones, however, in rare cases is observed in the facial bones. The current study presents the case of a 12-year-old female patient with a tumor in the mandibular body. Radiological imaging revealed a lesion with regular contours. The lesion was radically resected and his...

Diagnosis of osteoblastoma by fine-needle aspiration (FNA) is rare, as in most patients, excisional biopsy is performed. We report a case of FNA diagnosis of a spinal osteoblastoma in a lymphangiomatosis patient. The patient had a history of lymphangiomatosis since birth with lymphangiomas removed from various locations, and had radiograph evidence of multifocal vertebral involvement. He presen...

Osteoblastoma is an unusual neoplasm, usually found in the vertebral column and long bones of extremities. Maxillary involvement extremely rare. We present a case report benign osteoblastoma maxilla affecting 17 year old young male patient. The clinical presentation, radiological histopathological features as well treatment modalities this neoplasm are briefly discussed. Lastly attempt made to ...

Osteoblastoma was first described in 1956 by Lichenstein and Jaffe. It represents 0.8--1% of all bone tumors and affects young adults, with male preponderance. It predominantly affects the axial skeleton and vertebrae with only 14--20% of tumors affecting the skull. The most commonly affected sites are maxilla, temporal, sphenoid, occipital, ethmoid and frontal bones. Histologically it is a ben...

Forced-activation of AMP-activated protein kinase (AMPK) can possibly inhibit osteoblastoma cells. Here, we aim to provoke AMPK activation via microRNA silencing its phosphatase Ppm1e (protein phosphatase Mg2+/Mn2+-dependent 1e). We showed that microRNA-135b-5p ("miR-135b-5p"), the anti-Ppm1e microRNA, was significantly downregulated in human osteoblastoma tissues. It was correlated with Ppm1e ...