Background: The objective of this study is to evaluate the progesterone level (P Level) on the day of HCG triggering in GnRh agonist and antagonist protocols, and its correlation with clinical pregnancy rate and miscarriage rate. Premature luteinization during in vitro fertilization (IVF) was commonly happened before the introduction of GnRh analogues. High level of unwanted progesterone that i...

Non-keratinocyte cutaneous malignancies including breast cancer metastasis and melanoma in situ are often poor surgical candidates due to their anatomical location, size the morbidities associated with surgery. Imiquimod, a toll-like receptor 7 agonist, is used for treatment of these malignancies, which activates innate immunity skin. However, imiquimod’s modest effect on activation adaptive li...

Midodrine is a prodrug metabolized to the peripheral acting alpha agonist desglymidodrine and used treat orthostatic hypotension. Reports of overdose are rare, consequently there little gu...

Drugs altering serotonin levels have been reported to influence skin inflammation. Serotonin 2A receptor (HTR2A) is hypothesized play a key role in mediating inflammation as it widely-expressed on many immune cells and HTR2A partial agonist could attenuate imiquimod (IMQ)-induced psoriasiform murine model. Furthermore, analysis of data from GEO database has found mRNA expression be lower psoria...

Introduction: Adjuvant medications can be used to increase the analgesic effect of opioid analgesics, reduce manifestation side effects, and also for premedication. This paper provides information on clonidine, haloperidol, metocloparmide, diazepam, midazolam analgesics: - morphine selective kappa-opioid agonist compound RU-1205.
 Materials methods: A probable interaction between RU-1205, ...

introduction: previous studies have shown that ghrelin inhibits the activity of hypothalamus –pituitary – thyroid (h–p-t) axis. it is also proved that ghrelin increases appetite via agouti related protein and neuropeptide y pathway, decreases t3 & t4 secretion and inhibits serotonin release from hypothalamic synaptosomes. serotonin may interact with ghrelin in control of thyroid hormones secret...

objective:  to investigate the reproductive outcome of artificial endometrial preparation with exogenous steroids for frozen-thawed embryo transfer with and without pre-treatment with depot gonadotropin releasing hormone agonist (gnrh-a) in women with regular menses. amaterials and methods: this is a prospective randomized clinical trial conducted in two rt centers on 176 women undergoing froze...