نتایج جستجو برای: alad
تعداد نتایج: 242 فیلتر نتایج به سال:
Exposure to high levels of environmental lead, or biomarker evidence of high body lead content, is associated with anaemia, developmental and neurological deficits in children, and increased mortality in adults. Adverse effects of lead still occur despite substantial reduction in environmental exposure. There is genetic variation between individuals in blood lead concentration but the polymorph...
Child low-level lead (Pb) exposure is an unresolved public health problem and an unaddressed child health disparity. Particularly in cases of low-level exposure, source removal can be impossible to accomplish, and the only practical strategy for reducing risk may be primary prevention. Genetic biomarkers of increased neurotoxic risk could help to identify small subgroups of children for early i...
this study was aimed to investigate the effects of environmental pollution with heavy metals from ferro-nickel smelter on aminolevulinic acid dehydratase (alad) activity, and to analyze the blood lead level of feral pigeon ( columba livia ) in ferro-nickel smelter courtyard in drenas city, republic of kosovo. for this purpose, twenty specimens of feral pigeon (20 birds, males and females), were...
The mean dithiothreitol (DTT)-activated activity of erythrocytIc -aminolevulinate dehydratase (ALAD,EC 4.2.1.24, porphobilinogen synthase) in 20 nondiabetic subjects was 30.5 (SD 4.0) U per liter of erythrocytes; in 79 diabetics, this activity was 19.4 (SD 6.3) U/L, significantlyless (P <0.001). Further, we observed a significant (P <0.01) negative correlation between activated ALAD activity an...
The activity of 5-aminolevulinate dehydratase (ALAD) in rabbit blood is significantly inhibited by tin. Intravenous administration of tin (0.48 or 4.8 mumol/kg body weight) causes a decrease in the activity of the enzyme by 60% or 94% respectively. The effects of tin and lead on ALAD differ: inhibition by tin is not affected by pre-incubation at 50-60 degrees C, whereas the inhibitory effect of...
We report a number of X-ray analyses of an enzyme involved in a key early stage of tetrapyrrole biosynthesis. Two structures of human 5-aminolaevulinate dehydratase (ALAD), native and recombinant, have been determined at 2.8 Å resolution, showing that the enzyme adopts an octameric quaternary structure in accord with previously published analyses of the enzyme from a range of other species. How...
Lead is a ubiquitous environmental contaminant; nearly 5% of American children are affected by lead poisoning (a blood lead level (BLL) of 10 mgdL 1 or higher). Even lower BLLs have been shown to cause many subtle health effects in children. Lead, which is found in paint and soil, causes toxicity by several possible mechanisms. Pb interacts with several zinc enzymes or proteins (such as carboni...
Border, E. A., Cantrell, A. C., and Kilroe-Smith, T. A. (1976). British Journal of Industrial Medicine, 33, 85-87. The in vitro effect of zinc on the inhibition of human 8-aminolevulinic acid dehydratase by lead. The antagonistic effect of zinc on inhibition of human aminolevulinic acid dehydratase (ALAD) by lead was examined in vitro. The phenomenon was studied at pH 6 5-7 5. Zinc and lead wer...
Border, E. A., Cantrell, A. C., and Kilroe-Smith, T. A. (1976). British Journal of Industrial Medicine, 33, 85-87. The in vitro effect of zinc on the inhibition of human 8-aminolevulinic acid dehydratase by lead. The antagonistic effect of zinc on inhibition of human aminolevulinic acid dehydratase (ALAD) by lead was examined in vitro. The phenomenon was studied at pH 6 5-7 5. Zinc and lead wer...
The enzyme delta-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis, can be inhibited by several chemicals, including lead, a potential risk factor for brain tumors, particularly meningioma. In this study we examined whether the ALAD G177C polymorphism in the gene coding for ALAD is associated with risk of intracranial tumors of the brain and nervous syste...
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