Skeletal muscle necrosis is a common manifestation of viperid snakebite envenomations. Venoms from snakes of the genus Bothrops, such as that of B. asper, induce muscle tissue damage at the site of venom injection, provoking severe local pathology which often results in permanent sequelae. In contrast, the venom of the South American rattlesnake Crotalus durissus terrificus, induces a clinical ...

A mong the pattern recognition receptors (PRRs), the receptor for advanced glycation end-products (RAGE) has been shown to bind many damage-associated molecular patterns (DAMPs, also known as alarmins). DAMPs are released following tissue damage due to both infectious and non-infectious trauma whereby necrotic cells lose membrane integrity, causing their intracellular contents to leak into the ...

In the paper a new method, called the Noise Scattering Pattern (NSP) method, for RTS noise identification in a noise signal is presented. Examples of patterns of the NSP method are included.

one of the inflammatory mediators which is secreted by inflammatory cells is high-mobility group protein b1 (hmgb1). interaction of hmgb1 and toll-like receptors (tlrs) leads to increased production of inflammatory cytokines. on the other hand, it was shown that triggering receptor expressed on myeloid cells (trem-1) also can be activated by tlrs, and its soluble form (strem-1) can be formed by...

Inflammatory mediators play important roles in the development and progression of cancer. Cellular stress, damage, inflammation, and necrotic cell death cause release of endogenous damage-associated molecular pattern (DAMP) molecules or alarmins, which alert the host of danger by triggering immune responses and activating repair mechanisms through their interaction with pattern recognition rece...

Background Diagnosis of neonatal sepsis is complicated due to limited accuracy biochemical, microbiological and phenotypic parameters infection. Hence, early recognition fundamental in reducing the risk sepsis-related diseases mortality. As part innate immune defense mechanisms, inflammasomes sense exogen endogen danger signals thereby effecting secretion inflammatory mediators as well cell dea...