BACKGROUND Denmark has one of the highest alcohol consumption rates in Northern Europe. The overall per capita alcohol consumption has been stable in recent decades, but surveys have indicated that consumption has decreased in the young and increased in the old. However, there is no recent information on the epidemiology of alcoholic cirrhosis. We examined time trends in incidence, prevalence, ...

background there have been very few studies evaluating the close association between excess iron and cirrhosis; however, cirrhosis could be regarded as an iron-loading disorder. objectives in this study, the goal was to show the levels of the iron content in the liver tissue in certain types of cirrhosis. patients and methods in this 7 year study (2008 - 2014), in 1000 explanted livers, the amo...

Back Ground:Liver diseases are common disorders encountered in clinical practices. Investigations in liver diseases are used to detect hepatic abnormality, to measure its severity, to define it structural effect on the liver, to look for specific causes of liver diseases, assess prognosis and to evaluate therapy. Aim and Objectives:To study and compare the altered serum levels of enzymes GGT, A...

OBJECTIVE To evaluate the outcome of liver transplantation in patients with alcoholic cirrhosis with respect to selection criteria, survival, and evidence suggesting a return to harmful drinking. DESIGN Nine year retrospective study. SETTING Cambridge and King's College Hospital liver transplant programme. SUBJECTS 24 Patients (three women, 21 men) with alcoholic cirrhosis. MAIN OUTCOME...

Although altered cytokine homeostasis has been implicated in the pathogenesis of both alcoholic liver and pancreas diseases, the serum cytokine pattern characteristic of concomitant alcoholic liver cirrhosis and pancreatitis has not been examined. In this paper we examine the serum levels of proinflammatory cytokines, such as IL-6, IL-8, TNF-alpha, and also antiinflammatory ones, such as IL-10 ...

CONTEXT In about 10% of patients with chronic liver disease, it is not possible to identify an etiologic factor. These cases are called cryptogenic cirrhosis. Currently, nonalcoholic steatohepatitis (NASH) is being considered as a possible etiologic factor for a significant segment of patients that presents with cryptogenic cirrhosis. OBJECTIVE To estimate the prevalence of risk factors for N...

Sera from patients with chronic liver disease were tested for antibody against hepatitis B surface antigen by radioimmunoassay. The antibody was found in 25% of patients with alcoholic cirrhosis and in 52% when alcoholic cirrhosis was associated with portal hypertension, these results being significantly higher than in a matched control population. Other forms of chronic liver disease did not d...

BACKGROUND Interleukin (IL)-12 is a proinflammatory cytokine produced by antigen-presenting cells upon stimulation by diverse stimuli. This study aimed to explore the relationship between IL-12 serum levels and different stages of alcoholic liver disease, alcoholic intake status and abstinence from alcohol. METHODS A total of 35 healthy controls without alcohol consumption and 94 patients wit...

Gonadal function in male patients with various liver disease has been evaluated by basal plasma testosterone level and a response of plasma testosterone to human chorionic gonadotropin. Compared with healthy male subjects of similar age, gonadal function was not reduced in chronic hepatitis, but in alcoholic liver disease without cirrhosis and in alcoholic and non-alcoholic cirrhosis. Gonadal d...

The distributions of ABO, rhesus, and Lewis blood group antigens were studied in patients with alcoholic cirrhosis, alcoholic pancreatitis, chronic active hepatitis, and primary biliary cirrhosis. There were no differences in frequencies of ABO and rhesus blood group antigens between the groups or in comparison with a control group of blood donors. Lewis phenotype Le (a- b-), however, was more ...