Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control study was c...

Alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH) are among the most frequent causes of chronic liver disease in the United States. Although the two entities are triggered by different etiologies - chronic alcohol consumption (ASH) and obesity-associated lipotoxicity (NASH) - they share overlapping histological and clinical features owing to common pathogenic mechanisms. T...

Oxidative stress is frequently considered as a central mechanism of hepatocellular injury in non-alcoholic steatohepatitis (NASH). The aim of this study was to investigate the effects of fermented green tea extracts (FGTE) on NASH. Rats were fed a choline-deficient high-fat diet for 4 weeks to nutritionally generate fatty livers. NASH was induced chemically by oxidative stress using repeated in...

Dear Editor We read with great interest the article ‘Serum gamma glutamyl transferase and alanine transaminase concentrations predict endothelial dysfunction in patients with non-alcoholic steatohepatitis’ by Arinc et al. (1). They concluded that patients with non-alcoholic steatohepatitis (NASH) have impaired flow-mediated dilation (FMD) and increased carotid intima media thickness (cIMT) when...

Non-alcoholic steatohepatitis (NASH) is the potentially progressive form of non-alcoholic fatty liver disease (NAFLD). NAFLD and NASH are very common in most regions world on trajectory to become at a global scale. Risk for high prevalence progressiveness include visceral obesity Type 2 diabetes. The conundrum related rapid increase its burden with low awareness among general providers, as well...

The authors summarize and update the most recent knowledge in the field of prevalence, natural history and incidence of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH). These novel diseases, firstly recognized at the beginning of the second millennium, arose suddenly to the attention of the clinicians, because they are the hepatic expression of the "so-called"...

Non-alcoholic fatty liver (NAFL) is one of the most common liver diseases encountered in the United States and Europe. This term refers to a spectrum of hepatic pathology that resembles alcoholic liver disease, but appears in individuals who have low or negligible alcohol consumption. Initially the term non-alcoholic steatohepatitis (NASH) was employed by Ludwig et al. in 1980 to describe a syn...

Abstract Non‐alcoholic steatohepatitis (NASH) and alcohol‐associated (ASH) are the major cause of liver‐related mortality with limited therapeutic options available. In this study, we investigated role Src tyrosine kinase in pathogenesis (N)ASH. We examined expression livers from patients NASH, ASH, cirrhosis biliary atresia, preclinical mouse models: methionine choline deficient (MCD)‐diet‐ind...

NAFLD (non-alcoholic fatty liver disease) represents a spectrum of fatty liver diseases associated with an increased risk of Type 2 diabetes and cardiovascular disease. The spectrum of fatty liver diseases comprises simple steatosis, steatosis with inflammation [i.e. NASH (non-alcoholic steatohepatitis)], fatty liver disease with inflammation and fibrosis (severe NASH) and cirrhosis. The molecu...

Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of clinical entities ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) with possible evolution to cirrhosis and hepatocellular carcinoma. Iron is considered a putative element that interacts with oxygen radicals in inducing liver damage and fibrosis. The role of hepatic iron in the progression of NASH remains cont...