Aliphatic alcohols inhibited the activity of human matrix metalloproteinase 7 (matrilysin) competitively with K(i) of 6.1-19.4% (v/v) or 0.66-4.80 M. From the relationship between the structures of alcohols and their K(i) values, alcohols are considered to bind the hydrophobic S1' subsite most plausibly, and the size of the pocket was estimated to be large enough to accommodate the length of 1-...

Trimethylsilylation of alcohols and phenols were carried out under solvent-free conditions with hexamethyldisilazane (HMDS) using LaCoO3 perovskite. LaCoO3 as an efficient catalyst accelerated this reaction under milder condition. The advantages of this method are evident regarding, easy separation, low cost and low catalyst loading, lack of pollution, easy work-up, and selective protection of ...

A tandem electrosynthesis of homoallylic alcohols from alcohols in one-pot was realized. In virtue of this one-pot electrosynthesis, the traditional reaction substrates of allylation were broadened from carbonyl compounds to alcohols.

mn(ii) salen complex immobilized on nano silicagel was prepared by incorporating mn(ii) salen complex into a nanosilica matrix and characterized by tga, xrd, atomic absorption spectroscopy and was successfully applied as catalyst for the oxidation of alcohols. oxidation of a series of alcohols in acetonitrile over immobilized mn(ii) salen complex using tetrabutylammonium peroxymonosulfate (tbao...

The enantioselective silylation of racemic alcohols, where one enantiomer reacts faster than the other, is an alternative approach to established enzymatic and non-enzymatic acylation techniques. The existing art is either limited to structurally biased alcohols or requires elaborate catalysts. Simple substrates, such as benzylic and allylic alcohols, with no coordinating functionality in the p...

Esterification of several carboxylic acids with supercritical alcohols such as 1-propanol, 1butanol, 1-octanol, isoamylalcohol, ethanol, methanol, and subcritical benzyl alcohol without using any catalyst was studied. A variety of esters were synthesized very effectively using supercritical alcohols as solvent and reagent. Moderate to excellent yields were obtained depending on the nature of th...

Treatment of substituted benzyl alcohols with tosyl chloride resulted in the formation of the corresponding chlorides, not the usual tosylates. A series of experiments demonstrated that it was possible to predict whether chlorination or tosylation would occur for substituted benzyl alcohols and pyridine methanols. Treatment of electron withdrawing group-substituted benzyl alcohols with tosyl ch...

trimethylsilylation of a variety of alcohols and phenols, in the presence of silica chloride, using hexamethyldisilazane (hmds) in solution and under solvent-free conditions is reported. trimethylsilyl ethers were formed in excellent yields both for aliphatic alcohols and phenols without having an electron-withdrawing group. in addition, sio2-cl can be recovered and reused after drying.

Electrophysiological and behavioral studies were performed in rats to analyze the gustatory effects of alcohols, such as methanol, ethanol, ethylene glycol, 1-propanol, 2-propanol, propylene glycol, 1,3-propandiol, and glycerin. When the whole bundle responses to each of the alcohols at 1.0 M were recorded from the chorda tympani (CT) and glossopharyngeal nerve (Gl), the alcohols with two or th...

A novel, one-step synthesis of substituted pyridine- and quinoline-derivatives was achieved by acceptorless dehydrogenative coupling of γ-aminoalcohols with secondary alcohols. The reaction involves consecutive C-N and C-C bond formation, catalyzed by a bipyridyl-based ruthenium pincer complex with a base.