The first catalytic asymmetric synthesis of the key intermediate for beraprost has been achieved through an enantioselective intramolecular oxa-Michael reaction of an α,β-unsaturated amide mediated by a newly developed benzothiadiazine catalyst. The Weinreb amide moiety and bromo substituent of the Michael adduct were utilized for the C-C bond formations to construct the scaffold. All four cont...

In this paper we describe the new system ME-ASP, which applies machine learning techniques for inductively choosing, among a set of available ones, the “best” ASP solver on a per-instance basis. Moreover, we report the results of some experiments, carried out on benchmarks from the “System Track” of the 3rd ASP Competition, showing the state-of-the-art performance of our solver.

Answer Set Programming (ASP), a modern development of Logic Programming, enables natural integration Computing with STEM subjects. This addresses widely acknowledged challenge in K-12 education, and early empirical results on ASP-based are promising. Although ASP is considered simple language when compared imperative programming languages, errors can still be significant barrier for students. p...

We consider the mixed finite element approximation of axisymmetric Stokes problem (ASP) on a bounded polygonal domain in rz-plane. Standard stability results methods do not apply due to singular coefficients differential operator and or vanishing weights associated function spaces. develop new analysis these weighted spaces, propose macroelement conditions that are sufficient ensure well-posedn...

Answer Set Programming (ASP) is a problem modeling and solving framework for several problems in KR with growing industrial applications. Also studies of computational complexity deeper insights into the hardness its sources, ASP has been attracting researchers many years. These resulted fruitful characterizations terms classes, fine-grained form dichotomy-style results, as well detailed parame...

Abstract This review presents a reasoned synthesis of whole-school interventions seeking to improve the overall school environment by fostering active student participation (ASP) in activities and decision-making processes. The aims are describe selected programs, assess their methodological quality, analyze soliciting ASP. Among 205 publications initially provided literature search academic da...

Abstract Objective Chondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), traditional Chinese medicine, possesses anti-inflammatory and anti-apoptotic properties chondrocytes. This study aimed to determine the protective of ASP on sodium nitroprusside (SNP)-induced chondrocyte apoptosis, explore underlying mechanism. Method Human pri...

Abstract In answer set programming (ASP), the user can define declaratively a problem and solve it with efficient solvers; practical applications of ASP are countless several constraint problems have been successfully solved ASP. On other hand, solution time usually grows in superlinear way (often, exponential) respect to size instance, which is impractical for large instances. A widely used ap...

[reaction: see text] A diastereoselective tandem Stille-oxa-electrocyclization reaction provides access to the core of the diterpenoid natural product saudin. Additionally, this new reaction sequence was extended to the convergent preparation of related polycyclic pyran systems.

Abstract Objective Neurocysticercosis (NCC) is the most common parasitic disease of central nervous system. No stablished treatment exists for management subarachnoid NCC. We aim to present a minimally invasive procedure with basis on anterior Sylvian point (ASP) cistern Materials and methods Three patients histologically confirmed NCC followed targeted burr hole surgery reference ASP. prepared...