A Cu(II)-MOF (1') with open metal sites was readily obtained by removing the coordinated water molecule at 120 °C. It can be used as a probe to evidence the sec-alkyl hydroperoxide species generated from room temperature sec-alcohol auto-oxidation in air. The formed alkyl hydroperoxides can be effectively catalyzed by 1' to decompose into molecular oxygen and corresponding sec-alcohols under am...

An environmentally benign and practical preparation method for the Vilsmeier-Haack reagent (VH) has been developed by using phthaloyl dichloride with DMF in toluene or 2-chlorotoluene. Phthalic anhydride as the byproduct was recovered in high yield by simple filtration. Some aromatic acids have been transformed into the corresponding acid chlorides in good yields by employing the isolated VH. T...

N-alkyl amino acids find widespread application as highly valuable, renewable building blocks. However, traditional synthesis methodologies to obtain these suffer from serious limitations, providing a major challenge to develop sustainable alternatives. We report the first powerful catalytic strategy for the direct N-alkylation of unprotected α-amino acids with alcohols. This method is highly s...

Activation of primary alcohols in the presence KO t Bu/DMF allowed synthesis N -heteroarenes via alkylation C(sp 3 )–H bond methyl azaarenes. A mechanism involving formation an alkyl formate intermediate is proposed.

The composition of lipophilic extractives in the cortex and pith of elephant grass ( Pennisetum purpureum Schumach.) stems was thoroughly studied by gas chromatography-mass spectrometry. The predominant compounds were fatty acids followed by sterols (in free and conjugated forms as esters and glycosides). Other steroid compounds, as steroid hydrocarbons and ketones, were also present. Addition...

Various aryl and alkyl substituted optically pure propargyl alcohols were obtained with excellent ee (up to >99%) and isolated yields (up to 87%) by deracemization using whole cells of Candida parapsilosis ATCC 7330. The whole cells show substrate specificity towards alkyl substituted propargyl alcohols and a switch in the enantioselectivity has been observed from 'R' to 'S' upon increasing the...

The use of surface-bound alkyl and phenyl groups as synthetic vehicles in coupling reactions on oxygen-activated Au(111) is demonstrated by the formation of ethers via alkyl and phenyl iodides. Ethers are formed by successive additions of surface-bound alkyl groups to adsorbed atomic oxygen to form first the alkoxy and then the ether. The addition of the ethyl group to adsorbed oxygen on Au(111...

Conventional Suzuki–Miyaura arylations use halogenated compounds as electrophilic coupling partners. Although the catalytic activation of organohalides is well established, these substrates are seldom naturally abundant and questions exist to their metabolic environmental friendliness. Owing existence readily available chemical feedstocks, alcohols highly desirable cross-coupling partners, alth...

The stereoselective germylzincation of internal alkynes delivering trisubstituted vinylgermanes is achieved via a radical chain process involving Ph3GeH and Et2Zn with AIBN as initiator. Excellent levels regiocontrol are observed for non-symmetric (aryl, alkyl)-substituted alkynes, well propargylic alcohols aryl-, alkyl-, or silyl-substituted alkynes. reaction can be combined in one pot the Cu(...