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Background: Abacavir is an anti-retroviral medication used to treat HIV infected/AIDS patients and its efficacy has been proven in randomized clinical trials. The most significant adverse reaction associated with abacavir is the acute hypersensitivity phenomenon which manifests in many forms and in severe cases could result in death. Hypersensitivity reaction to abacavir has been closely linked...
Aim . To study the association of nucleotide polymorphisms in platelet receptor and cytochrome P450 genes with development resistance to antiplatelet drugs CHD patients. Material Methods The included 243 patients diagnosed after coronary artery bypass surgery (CABG), including 140 acetylsalicylic acid (ASA) treatment group 103 dual therapy (DAT) group. All were tested for aggregation using an o...
Wheat is a crop with spring and winter types and wide adaptability to different climate conditions. The wide adaptability of wheat is mainly controlled by three groups of genetic factors and among them vernalization (VRN) genes play pivotal role in determining spring and winter types. In this study, 395 Iranian wheat landraces were characterized with specific primer pairs designed based on VRN-...
A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) test was performed to investigate the allele frequencies of the insulin-like growth factor (IGF1 and IGF2 genes) in 90 broilerchickens. A 793 bp fragment of IGF1 gene and 1146 bp fragment of IGF2 gene were amplified and digested with HinfI and Hsp92II restriction enzymes,respectively. Two types of alleles of A and B...
Abstract The pollination of self-incompatible diploid sweet cherry is determined by the S-locus alleles. We resolved S-alleles 50 cultivars grown in Estonia and their incompatibility groups, which were previously unknown for most tested cultivars. used consensus primers SI-19/20, SI-31/32, PaConsI, PaConsII followed allele-specific sequencing to identify S-genotypes. Surprisingly, 48% (24/50) c...
Quantitative traits locus for milk production traits has been described on centromeric end of bovine chromosome 14. Reports name the acyl coA: diacylglycerol acyltransferase (DGAT1) gene as a potential candidate gene with dinucleotide substitution (AA to GC) in exon VIII which causes the change of lysine to alanine in amino acid (K232A).The aim of the present study was to estimate the frequency...
زمینه: ایزونیازید یکی از داروهای خط اول درمان سل می باشد که مقاومت به آن به صورت فزاینده ای گزارش می شود. در مطالعه حاضر دو روش مولکولی جهت تشخیص سریع مقاومت سویه های کلینیکی مایکوباکتریوم توبرکلوزیس به ایزونیازید طراحی و با نتایج سکوئنس مورد مقایسه قرار گرفتند. مواد و روش ها: در این مطالعه 60 سویه کلینیکی مایکوباکتریوم توبرکلوزیس، که با روش تعیین حساسیت دارویی (dst) مقاومت به ایزونیازید در آن ...
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