In previously reported in vitro studies, we found that heme, a physiologically widespread hydrophobic iron compound, can rapidly generate oxidized low-density lipoprotein (LDL), which then becomes cytotoxic to cultured vascular endothelial cells; both LDL oxidation and endothelial cytotoxicity were inhibited by incubation with exogenous alpha-tocopherol (vitamin E) or ascorbic acid (vitamin C)....

Intrapulmonary administration of bacterial lipopolysaccharide (LPS) induces a well-characterized lung inflammatory response involving alveolar macrophage activation, proinflammatory cytokine elaboration, and neutrophil influx. Vitamin E, a lipophilic antioxidant consisting of a family that includes tocopherols and tocotrienols, has previously been shown to have a variety of anti-inflammatory ef...

Label claims of vitamin E succinate and polyphenolic nutraceuticals are assessed. A validated HPLC method was utilized to assess vitamin E succinate products. Three novel LC/MS methods were used to assess the polyphenols, pterostilbene, phloretin, and myricetin, in dietary supplements. The amount of vitamin E succinate varied from 0-130% of the stated label content with two products containing ...

A 2 x 2 trial was conducted to determine the effects of injected vitamin A and dietary level of vitamin E on blood serum and tissue concentrations of alpha-tocopherol during early gestation of gilts. Thirty-two crossbred gilts were fed a corn soybean meal basal diet supplemented with DL-alpha tocopheryl acetate to provide either 25 or 500 IU of vitamin E/kg of diet. Gilts were fed daily 1.9 kg/...

Methods: Alpha tocopherol, gamma tocopherol, and retinol are assayed using fluorescence detection. Excitation/emission wavelengths are 295 nm/330 nm and 325 nm/470 nm for the analysis of both tocopherols and retinol, respectively. Retinol acetate is employed as the internal standard. The reversed phase method incorporates gradient elution with a mobile phase consisting of methanol and acetonitr...

Syntrophic acetate oxidation coupled to hydrogenotrophic methanogenesis has been identified as a significant anaerobic pathway in high-temperature (55°C) oil fields (1, 2). In a paper on acetate production from oil under sulfate-reducing conditions, Callbeck et al. (3) took note of that observation, only to emphatically state that “syntrophic acetate oxidation coupled to hydrogenotrophic methan...

1. 7- and 12-Methylbenz[a]anthracene were converted by rat-liver homogenates into the corresponding hydroxymethyl derivatives, products that are probably the 8,9-dihydro-8,9-dihydroxy and the 5,6-dihydro-5,6-dihydroxy derivatives, and a number of phenolic products. 2. Both hydrocarbons were converted into glutathione conjugates; that from 7-methylbenz[a]anthracene was also formed, together with...

The title compounds, [(1R,3R,4R,5R,6S)-4,5-bis-(acet-yloxy)-7-oxo-2-oxabi-cyclo[4.2.0]octan-3-yl]methyl acetate, C14H18O8, (I), [(1S,4R,5S,6R)-5-acet-yloxy-7-hy-droxy-imino-2-oxobi-cyclo-[4.2.0]octan-4-yl acetate, C11H15NO6, (II), and [(3aR,5R,6R,7R,7aS)-6,7-bis-(acet-yloxy)-2-oxo-octa-hydro-pyrano[3,2-b]pyrrol-5-yl]methyl acetate, C14H19NO8, (III), are stable bicyclic carbohydrate derivatives....

Twelve (Yorkshire) gilts were assigned to 2 dietary fat supplement groups starting at 57 d of gestation. Group 1 received no fat and Group 2 was supplemented with 5% Canola oil. Each group was supplemented with 0.1 ppm Se and 22 IU of DL-alpha-tocopherol acetate/kg of feed. Colostrum (d 0) and milk (7, 14, 21 and 28 d post partum) were sampled from gilts. At farrowing 3 piglets from each gilt o...

In the title compound, C(27)H(24)O(14), also known as 2,3-di-acetoxy-5-[(2RS,3RS)-3,5,7-triacetoxy-4-oxochromen-2-yl]phenyl acetate, the heterocyclic ring adopts a distorted half-chair conformation, with two C atoms displaced by 0.1775 (16) and -0.5950 (16) Å from the mean plane of the other four atoms. The dihedral angle between the aromatic rings is 57.81 (8)°. In the crystal, the mol-ecules ...