BACKGROUND Alternate day fasting (ADF; ad libitum "feed day", alternated with 25% energy intake "fast day"), is effective for weight loss and cardio-protection in obese individuals. Whether these effects occur in normal weight and overweight individuals remains unknown. This study examined the effect of ADF on body weight and coronary heart disease risk in non-obese subjects. METHODS Thirty-t...

BACKGROUND Alternate day modified fasting (ADMF) is an effective strategy for weight loss in obese adults. OBJECTIVE The objective of this study was to examine the dietary and physical activity adaptations that occur during short-term ADMF, and to determine how these modulations affect rate of weight loss. METHODS Sixteen obese subjects (12 women/4 men) completed a 10-week trial consisting ...

The relation between alternate-day fasting (ADF) and cardioprotection remains uncertain. In the present study, we examined the ability of modified ADF, with a low-fat (LF) vs high-fat (HF) background diet, to modulate adipose tissue physiology in a way that may protect against coronary heart disease. In a 4-week study, male C57BL/6 mice were randomized to 1 of 3 groups: (1) ADF-85%-LF (85% ener...

OBJECTIVE: Obesity is a worldwide health problem, with increasing prevalence associated with an increased risk of chronic diseases. Decrease in energy intake has been shown to lower the risk of coronary artery disease (CAD) in obese. The common form of dietary restriction is daily calorie restriction (CR). Another form is alternate-day fasting (ADF). The ability of modified ADF to facilitate we...

BACKGROUND Alternate day fasting (ADF; ad libitum intake "feed day" alternated with 75% restriction "fast day"), is effective for weight loss, but the safety of the diet has been questioned. Accordingly, this study examined occurrences of adverse events and eating disorder symptoms during ADF. FINDINGS Obese subjects (n = 59) participated in an 8-week ADF protocol where food was provided on t...

background: daily administration of thyroxine has proven efficacy in treatment of children with hypothyroidism. however, the possibility of treatment with longer dosing intervals that offers flexibility and choice in maintaining euthyroid state has not been tested in children. objectives: to study the efficacy of an alternate day regimen to maintain euthyroidism in children with congenital hypo...

Although calorie restriction and alternate-day fasting have potential for slowing the aging process while decreasing risk for vascular disease, diabetes, cancer and dementia, a “carbohydrate-concentrated” diet strategy, entailing long daily periods of carbohydrate abstinence, may prove to be a much more practical strategy for achieving these aims. The life extension and healthy aging benefits o...