The effects of an antacid containing magnesium and aluminum hydroxide on the pharmacokinetics of pefloxacin in 10 healthy volunteers were investigated. In a randomized crossover design, each subject received an oral dose of 400 mg of pefloxacin either with or without multiple doses of the antacid. The concentrations of pefloxacin and its metabolites in plasma and urine were determined by high-p...

BACKGROUND The 23-amino acid extracellular domain of matrix 2 protein (M2e) and the internal nucleoprotein (NP) of influenza are highly conserved among viruses and thus are promising candidate antigens for the development of a universal influenza vaccine. Various M2e- or NP-based DNA or viral vector vaccines have been shown to have high immunogenicity; however, high cost, complicated immunizati...

This study examined the effects of widely used antacids (aluminum hydroxide, magnesium oxide, and calcium carbonate), ferrous sulfate, and ranitidine on the absorption of a fluorinated quinolone, (-)-(S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro- 7H- pyrido-[1,2,3,-de][1,4]benzoxazine-6-carboxylic acid hemihydrate (DR-3355), in healthy male volunteers enrolled in three sep...

A method for controlling the gastric pH of rabbits to low acidity (pH > 4) by using different antacids was investigated, and the physiological state of rabbits during gastric-acidity control and repeated bioavailability tests was also examined in terms of hemocytological and clinicobiochemical parameters. Neither dried aluminum hydroxide gel (DAH) nor synthetic aluminum silicate (SAS) could ele...

A system for the regeneratlon of caustic soda solutlons used In etching aluminum Invokes the hydrolysis of sodium aluminate to llberate free sodium hydroxide and produce a dry, crystalllne hydrated alumlna byproduct. The system has been used extenslvely In Japan, and, by adjusting process parameters, can be adapted to North American practice. By otlllting the system in a typical plant, soild ai...

Studies were conducted to compare the phosphate-binding efficacy of lanthanum carbonate directly with other clinically used phosphate binders and to evaluate any potential adverse pharmacology. To examine the phosphate-binding efficacy, rats with normal renal function and chronic renal failure received lanthanum carbonate, aluminum hydroxide, calcium carbonate, or sevelamer hydrochloride in sev...

Calcium carbonate appears to be as effective as aluminum hydroxide in binding dietary phosphorus in hemodialysis patients. The long-term safety of this medication appears acceptable in view of today's therapeutic options.

An equilibrium model for the speciation of Al3+ in normal serum has been developed in which 81% of the aluminum is bound to transferrin. The remaining 19% exists primarily as Al(PO4)(OH)-, with minor amounts of citrate and hydroxide species. The model meets several key criteria. The concentration of free aluminum is below the upper limit set by the solubility product of aluminum phosphate. The ...