Nowadays, many people prefer to use herbal remedies instead of chemical treatments, because of a fewer side effects. It seems that herbal drugs can be useful to neuroinflammation diseases like Alzheimer. Alzheimer Disease (AD) is caused by the oxidative stress and inflammatory compounds such as cytokine and beta-amyloid. It causes learning problems due to damage in cells in the hippocampus area...

One of the most serious neurodegenerative disorders is Alzheimer disease (AD). As the population is aging and due to the fact that AD is more common in aged people, more attention must be paid to this disease. One of the main characteristics of AD is dementia which starts with loss of short term memory, then progresses and causes various brain dysfunctions such as loss of long term memory. Inte...

Alzheimer disease is characterized by cerebral Abeta deposition, which we have recently discovered occurs also in the lens as cataracts in Alzheimer disease patients. Here we report the presence of significantly increased cataracts in the lenses of an Abeta-transgenic mouse model for Alzheimer disease and their amelioration upon treatment with EUK-189, a synthetic SOD/catalase mimetic. These da...

Hesperetin (Hst) is a well-known bioflavonoid, has low bioavailability. Hesperetin nanoparticles (Nano-Hst) enhance its bioavailability. Nano-Hst were not explored for their potential therapeutic activities in Alzheimer’s disease (AD). Hence, the present study was performed to evaluate the protective effect of Nano-Hst in comparison to free Hesperetin on against intracerebroventricular in...

Of the many causes of dementia, Alzheimer disease (AD) is most common. Diagnosis generally followed by treatment. One common treatments AD a type medication called acetylcholinesterase inhibitors (ChEIs). ChEIs work blocking breakdown chemical in brain acetylcholine. In doing so, allows more this to be available brain. This can improve or maintain cognition and memory.

objective(s): intracerebral injection of bone marrow stromal cells (bmscs) is being investigated as a therapeutic tool to prevent alzheimer's disease (ad). our aim was to investigate the effects of bmscs by intrathecal injection in ad rat model. materials and methods: bmscs were obtained from the bone marrow of wistar rat and transplanted into ad rat model via intrathecal injection. the ra...

alzheimer's disease (ad), the most ordinary form of dementia and extracellular accumulation of amyloid-β (aβ) in senile plaques, is an important and a main event in the pathogenesis of ad. deposition of aβ peptide initiates a spectrum of cellular responses that are interposed by the resident neuroimmune cells of the brain, the microglia. recently, a novel inflammasome signaling  pathway ha...

Dementia involves several factors, and it is required to administer an agent with efficiencies for its treatment. Sake known have antioxidant anti-inflammatory properties improves the serum concentration of BDNF. This study aimed evaluate neuroprotective action Japanese sake yeast on dementia Alzheimer disease type in rats by behavioral evaluation neurobiochemical assessment. The were grouped a...

The purpose of the study was to condense existing scientific evidence about the relation between aluminum (Al) exposure and risk for the development of Alzheimer's Disease (AD), evaluating its long-term effects on the population's health. A systematic literature review was carried out in two databases, MEDLINE and LILACS, between 1990 and 2005, using the uniterms: "Aluminum exposure and Alzheim...

background: alzheimer's disease (ad) is a complex neurodegenerative disorder characterized by accumulation of extracellular amyloid-β plaques and intracellular neurofibrillary tangles tau protein. obesity significantly increases the risk of developing ad. leptin is a peptide hormone secreted by adipocytes. in the present study the serum levels of leptin in ad was evaluated. material and method:...