One of the most important social problems that many of the developed countries face is the constant rise of the percentage of the elderly population values. A major health issue affecting this part of the population is the appearance of dementia of the Alzheimers type (AD) which is the most common case of dementia, affecting around 50 million people worldwide. In addition, the frequency of the ...

Aquaporin 4 (AQP4), which is the predominant aquaporins (AQPs) isoform in the adult brain, is specifically localized to astrocytes. Current findings regarding AQP4 and various neurological diseases have initiated our interest in unraveling the mystery of AQP4 function in Alzheimer’s disease (AD), which is a progressive neurodegenerative disorder characterized by the loss of memory and cognitive...

Cohen AD, Price JC, Weissfeld LA, James J, Rosario BL, Bi W, et al. Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve. J Neurosci 2009; 29: 14770–8. Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, et al. Phase 3 trials of solanezumab for mild-tomoderate Alzheimer’s disease. N Engl J Med 2014; 370: 311–21...

Over the past three decades, definition and diagnostic boundaries of Alzheimers disease (AD) have been repeatedly revised due to significant progress in understanding pathogenesis neurodegeneration associated with development high-tech methods. The current approach AD diagnostics relies on detection biomarkers that reflect two main neuropathological processes involved primary underlies AD: abno...

Background Despite the important role of amyloid-beta protein (Aβ) in initiation and progression Alzheimer’s Disease (AD), precise mechanism by which Aβ disrupts neuronal activity (NA) structure during disease development, whether this is an appropriate therapeutic target still controversial. Recently, we introduced several novel NA metrics (Kazemeifar, PLoS One 2017; Haddad, ISMRM 2019) based ...