Amiodarone was selectively perfused into the sinus node artery and atrioventricular node artery of 51 dogs. Amiodarone had an immediate negative chronotropic and dromotropic effect. Threshold concentration was 2.5 micrograms/ml. 25 and 50 micrograms/ml of amiodarone injected into the sinus node artery slowed the heart by 25.6 +/- 3.1 and 33.7 +/- 2.6 beats/min (mean +/- 1 SEM), respectively. Am...

Comment Evidence of thyroid autoimmunity has often been noted in patients who develop hypothyroidism while receiving amiodarone.2 Between 30% and 50% of patients who have hypothyroidism induced by amiodarone iodine have antithyroid antibodies.' 2 Antithyroid antibodies are less common in patients who have hyperthyroidism induced by amiodarone iodine. Monteiro et al reported the development of a...

BACKGROUND In patients with coronary artery disease and reduced ejection fraction, amiodarone reduces mortality by decreasing sudden death. Because the latter may be triggered by coronary artery thrombosis as much as ventricular arrhythmias, amiodarone might interfere with tissue factor (TF) expression and thrombus formation. METHODS AND RESULTS Clinically relevant plasma concentrations of am...

OBJECTIVES Atrial fibrillation (AF) is a common complication after cardiac surgery. Topical amiodarone on the epicardium may help prevent postoperative AF while avoiding the side effects of its systemic administration. The purpose of this study was to evaluate the all-comer strategy of epicardial amiodarone application for the prevention of postoperative AF. METHODS A retrospective observatio...

Amiodarone-induced interstitial pneumonitis is a serious, frequently fatal untoward effect of a commonly used antiarrhythmic agent. Recent reports suggest that bronchoalveolar lavage (BAL) fluid cellular analysis might be used to diagnose amiodarone-induced pneumonitis. The purpose of this study was to determine if the diagnosis of amiodarone-induced pneumonitis could be made by patient history...

OBJECTIVES We sought to compare the efficacy and safety of dronedarone versus amiodarone for the prevention of recurrent atrial fibrillation (AF). BACKGROUND Dronedarone is a noniodinated amiodarone congener developed to maintain sinus rhythm. Few data are available to directly compare the efficacy and safety of dronedarone versus amiodarone. METHODS We conducted a systematic overview of al...

BACKGROUND/AIMS Most current knowledge regarding amiodarone toxicity derives from clinical trials. This study was performed to investigate the incidence and risk factors of overall adverse effects of amiodarone in real-world practice using a large sample size. METHODS Between January 1, 2000 and March 10, 2012, a total of 930 consecutive patients who had been treated with amiodarone for arrhy...

No prospective studies have compared sotalol and amiodarone during electropharmacologic testing. The purpose of this prospective, randomized study was to compare the electrophysiologic effects of sotalol and amiodarone in patients with coronary artery disease and sustained monomorphic ventricular tachycardia (VT). Patients with coronary artery disease and sustained monomorphic VT inducible by p...

Amiodarone, a bi-iodinated benzofuran derivative, is widely used for arrhythmias. Many patients benefit from the effectiveness of amiodarone in treating potentially life-threatening arrhythmias. However, amiodarone-induced pulmonary toxicity (APT) is a severe complication. Even after the discontinuation of amiodarone, not only is APT difficult to manage, but there is also a potentially life-thr...

abstract background: phlebitis is the most common complication associated with peripheral intravenous infusion of amiodarone. the purpose of this study is to determine the effects of sesame oil on the prevention of amiodarone‑induced phlebitis. materials and methods: this is a double‑blind randomized controlled trial. thirty‑six patients hospitalized in a coronary care unit were randomly alloca...