Altered striatal dopaminergic neurotransmission is thought to be fundamental to schizophrenia. Increased presynaptic dopaminergic activity ([18F]-DOPA PET) may predate the onset of psychotic symptoms and correlates to clinical symptoms in subjects at Ultra High Risk (UHR) for developing psychosis. Postsynaptic dopaminergic neurotransmission has not been investigated yet in UHR patients. We hypo...

Circadian activity rhythms are jointly controlled by a master pacemaker in the hypothalamic suprachiasmatic nuclei (SCN) and by food-entrainable circadian oscillators (FEOs) located elsewhere. The SCN mediates synchrony to daily light-dark cycles, whereas FEOs generate activity rhythms synchronized with regular daily mealtimes. The location of FEOs generating food anticipation rhythms, and the ...

Animal treading can change soil physical properties, and thus is an important factor in hydrological modelling. We investigated the impacts of animal treading on infiltration by using a series of rainfall simulation experiments at Whatawhata Research Center, Waikato, New Zealand. The study identified significant variables for estimating soil steady-state infiltration at a microsite (0Ð5 m2) and...

Deficiencies in Complex I have been observed in Parkinson's disease (PD) patients. Systemic exposure to rotenone, a Complex I inhibitor, has been shown to lead to selective dopaminergic cell death in vivo and toxicity in many in vitro models, including dopaminergic cell cultures. However, it remains unclear why rotenone seems to affect dopaminergic cells more adversely. Therefore, the role of d...

Asphalt pavement itself is a mixture made up of mainly aggregates, binders, and fillers that acts as a composition used for pavement construction. An experimental program was setup to determine the fatigue performance test of Asphalt with three different grades of conventional binders. Asphalt specimen has achieved the maximum optimum bulk density and air voids with a consistent bulk density of...

OBJECTIVES This study was conducted to clarify the analgesic effect of toad cake and toad-cake-containing herbal drugs. METHODS We counted the writhing response of mice after the intraperitoneal administration of acetic acid as a nociceptive pain model and the withdrawal response after the plantar surface stimulation of the hind paw induced by partial sciatic nerve ligation of the mice as a n...

Recently, the PHENIX Collaboration has published second- and third-harmonic Fourier coefficients $v_2$ $v_3$ for midrapidity ($|\eta|<0.35$) charged hadrons in 0\%--5\% central $p$$+$Au, $d$$+$Au, $^3$He$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV utilizing three sets of two-particle correlations two detector combinations with different pseudorapidity acceptance [Phys. Rev. C {\bf 105}, 02490...