Almond and sweet cherry are two economically important species of the Prunus genus. They both produce the cyanogenic glucosides prunasin and amygdalin. As part of a two-component defense system, prunasin and amygdalin release toxic hydrogen cyanide upon cell disruption. In this study, we investigated the potential role within prunasin and amygdalin and some of its derivatives in endodormancy re...

There have been only two large-scale clinical studies on the impact of Laetrile (amygdalin) on cancer. In one of them, Ellison, Byar and Newell (1978) reviewed cases in which Laetrile was thought to be of help. Those who have cited this study have come to very different interpretations, however, some concluding that it showed that Laetrile was effective and some concluding that it was not. A re...

Durch die REGA erfolgte Vorstellung eines 71-jährigen Patienten mit akuter Dyspnoe. Ungefähr 30–60 Minuten vor deren Auftreten hatte er sechs Tabletten amygdalinhaltigen Nahrungsergänzungsmittels eingenommen.

BACKGROUND TNF-α is an inflammatory cytokine that plays an important role in insulin resistance observed in obesity and chronic inflammation. Many cellular components involved in insulin signaling cascade are known to be inhibited by TNF-α. Insulin receptor substrate (IRS)-1 is one of the major targets in TNF-α-induced insulin resistance. The serine phosphorylation of IRS-1 enables the inhibiti...

Chaenomeles fruits are being applied more frequently, mainly due to its high content of bioactive compounds and their positive effect on health condition. Currently, they raw materials in pharmaceutical, cosmetic food industries. The aim work was characterize cultivar Cido japonica two varietal hybrids: x californica Gold Kalif Maksim under mineral, vitamins, antiradical capacity, organic acids...

BACKGROUND The Chinese medicine formulation ISF-1 (also known as Bu-Yang-Huan-Wu-Tang) for post-stroke rehabilitation could increase the expression of growth-regulating protein follistatin by approximately 4-fold. This study aims to identify the active compounds of ISF-1 for the induction of follistatin expression. METHODS Active compounds in ISF-1 responsible for induction of follistatin wer...

cyanogenesis in prunus species produces‎‏ ‏cyanogenic glycosides such as‏ ‏monoglycoside ‎prunasin and digelicosede amygdalin. despite the mechanism of almond bitterness inheritance ‎has been known, biosynthesis cycle of cyanogenic compounds among different genotypes is still ‎unclear. total soluble proteins of fruits was extracted from collected sweet and bitter almond ‎genotypes and was studi...

A near-infrared sensor for cyanide ion (CN(-)) was developed via internal charge transfer (ICT). This sensor can selectively detect CN(-) either through dual-ratiometric fluorescence (logarithm of I414/I564 and I803/I564) or under various absorption (356 and 440 nm) and emission (414, 564 and 803 nm) channels. Especially, the proposed method can be employed to measure β-glucosidase by detecting...